MRE11A - Double-strand break repair protein MRE11A - human protein (Function)
 
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MRE11A »  Double-strand break repair protein MRE11A
 
Protein also known as:  Meiotic recombination 11 homolog 1 (MRE11 homolog 1).
Gene name:  MRE11A
Family name: MRE11/RAD32
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 145 2
GENE REF ISO

Function

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Overview 
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.  
  • CuratedUniProtKB
GO molecular function 
3'-5' exonuclease activitydefinition[GO:0008408]  
1
  • TASPINC
Contributes to ATP-dependent DNA helicase activitydefinition[GO:0004003]  
1
  • IMPBHF-UCL
Contributes to DNA bindingdefinition[GO:0003677]  
1
  • IDABHF-UCL
Double-stranded DNA bindingdefinition[GO:0003690]  
1
  • TASPINC
Endodeoxyribonuclease activitydefinition[GO:0004520]  
1
  • TASPINC
Manganese ion bindingdefinition[GO:0030145] silver  
  • IEAInterPro 2 GO
Nuclease activitydefinition[GO:0004518]  
1
  • TASBHF-UCL
Protein bindingdefinition[GO:0005515]  
8
  • IPIIntAct
  • IPIUniProtKB
Protein C-terminus bindingdefinition[GO:0008022]  
1
  • IPIUniProtKB
Single-stranded DNA endodeoxyribonuclease activitydefinition[GO:0000014]  
1
  • TASPINC
GO biological process 
Cell proliferationdefinition[GO:0008283] silver  
  • IEAOrtholog Compara
Cellular response to DNA damage stimulusdefinition[GO:0006974]  
1
  • IDAMGI
DNA catabolic process, endonucleolyticdefinition[GO:0000737]  
2
  • TASGOC
DNA duplex unwindingdefinition[GO:0032508]  
1
  • IMPBHF-UCL
DNA recombinationdefinition[GO:0006310]  
1
  • TASPINC
Double-strand break repair via nonhomologous end joiningdefinition[GO:0006303]  
1
  • TASPINC
Intra-S DNA damage checkpointdefinition[GO:0031573] silver  
  • IEAOrtholog Compara
Mitotic G2 DNA damage checkpointdefinition[GO:0007095] silver  
  • IEAOrtholog Compara
Negative regulation of DNA endoreduplicationdefinition[GO:0032876]  
1
  • IMPBHF-UCL
Nucleic acid phosphodiester bond hydrolysisdefinition[GO:0090305]  
2
  • TASGOC
Positive regulation of kinase activitydefinition[GO:0033674]  
1
  • IDABHF-UCL
Positive regulation of protein autophosphorylationdefinition[GO:0031954]  
1
  • IDABHF-UCL
Reciprocal meiotic recombinationdefinition[GO:0007131]  
2
  • TASPINC
Regulation of mitotic recombinationdefinition[GO:0000019]  
1
  • TASPINC
Sister chromatid cohesiondefinition[GO:0007062]  
1
  • IMPBHF-UCL
Synapsisdefinition[GO:0007129] silver  
  • IEAOrtholog Compara
Telomere maintenance via telomerasedefinition[GO:0007004]  
2
  • TASPINC
Enzymatic activity 
It requires the following cofactor
Manganese (By similarity).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Homologous recombination  hsa03440+4361  
Non-homologous end-joining  hsa03450+4361  
According to Reactome, this protein belongs to the following pathways:
Cell Cycle  REACT_115566  
Cellular responses to stress  REACT_120956  
DNA Repair  REACT_216  
Immune System  REACT_6900  
Note 
In case of infection by adenovirus E4, the MRN complex is inactivated and degraded by viral oncoproteins, thereby preventing concatenation of viral genomes in infected cells.  
  • CuratedUniProtKB
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
Meiosis  definition   [KW-0469]
Molecular function 
Endonuclease  definition   [KW-0255]
Exonuclease  definition   [KW-0269]
Hydrolase  definition   [KW-0378]
Nuclease  definition   [KW-0540]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MRE11A
GenomeRNAi: 4361
PRO: PR:P49959