AGTR2 - Type-2 angiotensin II receptor - human protein (Function)
 
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AGTR2 »  Type-2 angiotensin II receptor
 
Protein also known as:  Angiotensin II type-2 receptor (AT2).
Gene name:  AGTR2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.  
1
  • CuratedUniProtKB
GO molecular function 
Angiotensin type II receptor activitydefinition[GO:0004945]  
1
  • IPIBHF-UCL
Peptide hormone bindingdefinition[GO:0017046] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIBHF-UCL
Receptor antagonist activitydefinition[GO:0048019]  
1
  • TASBHF-UCL
Transcription factor bindingdefinition[GO:0008134] silver  
  • IEAOrtholog Compara
GO biological process 
Aldosterone secretiondefinition[GO:0035932] silver  
  • IEAOrtholog Compara
Angiotensin-activated signaling pathwaydefinition[GO:0038166]  
2
  • IPIGOC
Behaviordefinition[GO:0007610] silver  
  • IEAOrtholog Compara
Blood vessel remodelingdefinition[GO:0001974]  
1
  • TASBHF-UCL
Brain developmentdefinition[GO:0007420]  
1
  • NASBHF-UCL
Brain renin-angiotensin systemdefinition[GO:0002035] silver  
  • IEAOrtholog Compara
Cell growth involved in cardiac muscle cell developmentdefinition[GO:0061049] silver  
  • IEAOrtholog Compara
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • IDABHF-UCL
Cellular response to dexamethasone stimulusdefinition[GO:0071549] silver  
  • IEAOrtholog Compara
Cellular sodium ion homeostasisdefinition[GO:0006883] silver  
  • IEAOrtholog Compara
Cerebellar cortex developmentdefinition[GO:0021695] silver  
  • IEAOrtholog Compara
Dopamine biosynthetic processdefinition[GO:0042416] silver  
  • IEAOrtholog Compara
Extracellular negative regulation of signal transductiondefinition[GO:1900116]  
1
  • TASGOC
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • ICBHF-UCL
G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messengerdefinition[GO:0007199]  
1
  • ISSBHF-UCL
Inflammatory responsedefinition[GO:0006954] silver  
  • IEAOrtholog Compara
Intracellular signal transductiondefinition[GO:0035556]  
1
  • ISSBHF-UCL
Negative regulation of blood vessel endothelial cell migrationdefinition[GO:0043537]  
1
  • NASBHF-UCL
Negative regulation of cell growthdefinition[GO:0030308]  
1
  • TASBHF-UCL
Negative regulation of fibroblast proliferationdefinition[GO:0048147] silver  
  • IEAOrtholog Compara
Negative regulation of heart ratedefinition[GO:0010459]  
  • ISSOrtholog Curator
Negative regulation of icosanoid secretiondefinition[GO:0032304] silver  
  • IEAOrtholog Compara
Negative regulation of neurotrophin TRK receptor signaling pathwaydefinition[GO:0051387]  
1
  • IMPBHF-UCL
Negative regulation of norepinephrine secretiondefinition[GO:0010700] silver  
  • IEAOrtholog Compara
Nitric oxide mediated signal transductiondefinition[GO:0007263]  
2
  • TASBHF-UCL
Positive regulation of branching involved in ureteric bud morphogenesisdefinition[GO:0090190] silver  
  • IEAOrtholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
  • IEAOrtholog Compara
Positive regulation of cytokine secretiondefinition[GO:0050715] silver  
  • IEAOrtholog Compara
Positive regulation of extrinsic apoptotic signaling pathwaydefinition[GO:2001238]  
1
  • IMPBHF-UCL
Positive regulation of metanephric glomerulus developmentdefinition[GO:0072300] silver  
  • IEAOrtholog Compara
Positive regulation of nitric oxide biosynthetic processdefinition[GO:0045429]  
1
  • ICBHF-UCL
Positive regulation of nitric-oxide synthase activitydefinition[GO:0051000]  
1
  • ISSBHF-UCL
Positive regulation of phosphoprotein phosphatase activitydefinition[GO:0032516]  
1
  • IDABHF-UCL
Positive regulation of renal sodium excretiondefinition[GO:0035815] silver  
  • IEAOrtholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893] silver  
  • IEAOrtholog Compara
Positive regulation of vasodilationdefinition[GO:0045909]  
2
  • IDABHF-UCL
Regulation of blood pressuredefinition[GO:0008217]  
1
  • TASPINC
Regulation of metanephros sizedefinition[GO:0035566] silver  
  • IEAOrtholog Compara
Regulation of systemic arterial blood pressure by circulatory renin-angiotensindefinition[GO:0001991]  
  • ISSOrtholog Curator
Regulation of transcription factor import into nucleusdefinition[GO:0042990] silver  
  • IEAOrtholog Compara
Renin-angiotensin regulation of aldosterone productiondefinition[GO:0002018] silver  
  • IEAOrtholog Compara
Response to organonitrogen compounddefinition[GO:0010243] silver  
  • IEAOrtholog Compara
Vasodilation by angiotensin involved in regulation of systemic arterial blood pressuredefinition[GO:0002033] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Neuroactive ligand-receptor interaction  hsa04080+186  
Renin-angiotensin system  hsa04614+186  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
Caution 
Although AGTR2 has been reported to be involved in X-linked mental retardation (PubMed12089445), its pathological role is questionable (PubMed23871722).  
2
  • CuratedUniProtKB
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Angiotensin_II_receptor_type_2
GenomeRNAi: 186
PRO: PR:P50052
Chemistry
GuidetoPHARMACOLOGY: 35