IDH3A - Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial - human protein (Function)
 
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IDH3A »  Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial   [ EC 1.1.1.41 ]
 
Protein also known as:  Isocitric dehydrogenase subunit alpha.
Gene name:  IDH3A
Entry whose protein(s) existence is based on evidence at protein level
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1 17 2
GENE REF ISO

Function

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GO molecular function 
Isocitrate dehydrogenase (NAD+) activitydefinition[GO:0004449]  
  • IEAEC 2 GO
Magnesium ion bindingdefinition[GO:0000287] silver  
  • IEAInterPro 2 GO
NAD bindingdefinition[GO:0051287] silver  
  • IEAInterPro 2 GO
GO biological process 
Carbohydrate metabolic processdefinition[GO:0005975]  
1
  • NASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.1.1.41: Isocitrate + NAD(+) 2-oxoglutarate + CO(2) + NADH.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 magnesium or manganese ion per subunit (By similarity).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Citrate cycle (TCA cycle)  hsa00020+3419  
Metabolic pathways  hsa01100+3419  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Biological process 
Tricarboxylic acid cycle  definition   [KW-0816]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P50213
Other
GeneWiki: IDH3A
GenomeRNAi: 3419
PRO: PR:P50213