MMP14 - Matrix metalloproteinase-14 - human protein (Function)
 
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MMP14 »  Matrix metalloproteinase-14   [ EC 3.4.24.80 ]  (MMP-14)
 
Protein also known as:  Membrane-type-1 matrix metalloproteinase (MT1MMP).
Gene name:  MMP14
Family name: Peptidase M10A
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2.  
3
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Integrin bindingdefinition[GO:0005178] silver  
  • IEAOrtholog Compara
Metalloendopeptidase activitydefinition[GO:0004222] silver  
  • IEAInterPro 2 GO
Peptidase activator activitydefinition[GO:0016504] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
6
  • IPIIntAct
  • IPIUniProtKB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAOrtholog Compara
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Angiogenesisdefinition[GO:0001525] silver  
  • IEAOrtholog Compara
Astrocyte cell migrationdefinition[GO:0043615] silver  
  • IEAOrtholog Compara
Branching morphogenesis of an epithelial tubedefinition[GO:0048754] silver  
  • IEAOrtholog Compara
Endothelial cell proliferationdefinition[GO:0001935] silver  
  • IEAOrtholog Compara
Lung developmentdefinition[GO:0030324] silver  
  • IEAOrtholog Compara
Male gonad developmentdefinition[GO:0008584] silver  
  • IEAOrtholog Compara
Negative regulation of focal adhesion assemblydefinition[GO:0051895] silver  
  • IEAOrtholog Compara
Ossificationdefinition[GO:0001503] silver  
  • IEAOrtholog Compara
Ovarian follicle developmentdefinition[GO:0001541] silver  
  • IEAOrtholog Compara
Positive regulation of cell growthdefinition[GO:0030307]  
1
  • IDAUniProtKB
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • IDAUniProtKB
Proteolysisdefinition[GO:0006508]  
1
  • TASPINC
Response to estrogendefinition[GO:0043627] silver  
  • IEAOrtholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
  • IEAOrtholog Compara
Response to mechanical stimulusdefinition[GO:0009612] silver  
  • IEAOrtholog Compara
Response to oxidative stressdefinition[GO:0006979] silver  
  • IEAOrtholog Compara
Tissue remodelingdefinition[GO:0048771] silver  
  • IEAOrtholog Compara
Zymogen activationdefinition[GO:0031638] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.24.80: Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn-|-Leu-38. Other bonds hydrolyzed include 35-Gly-|-Ile-36 in the propeptide of collagenase 3, and 341-Asn-|-Phe-342, 441-Asp-|-Leu-442 and 354-Gln-|-Thr-355 in the aggrecan interglobular domain.  
  • CuratedUniProtKB
It requires the following cofactors
Binds 1 zinc ion per subunit (By similarity).  
  • CuratedUniProtKB
Calcium (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
GnRH signaling pathway  hsa04912+4323  
According to Reactome, this protein belongs to the following pathway:
Extracellular matrix organization  REACT_118779  
 
More information is available from:
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MMP14
GenomeRNAi: 4323
PRO: PR:P50281