MMP14 - Matrix metalloproteinase-14 - human protein (Function)
 
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MMP14 »  Matrix metalloproteinase-14   [ EC 3.4.24.80 ]  (MMP-14)
 
Protein also known as:  Membrane-type matrix metalloproteinase 1 (MTMMP1).
Gene name:  MMP14
Family name: Peptidase M10A
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2.  
4
  • UniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
1
  • InterPro 2 GO
Integrin bindingdefinition[GO:0005178] silver  
1
  • Ortholog Compara
Metalloendopeptidase activitydefinition[GO:0004222] silver  
1
  • InterPro 2 GO
Peptidase activator activitydefinition[GO:0016504] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
8
  • IntAct
  • UniProtKB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
1
  • Ortholog Compara
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Angiogenesisdefinition[GO:0001525] silver  
1
  • Ortholog Compara
Astrocyte cell migrationdefinition[GO:0043615] silver  
1
  • Ortholog Compara
Branching morphogenesis of an epithelial tubedefinition[GO:0048754] silver  
1
  • Ortholog Compara
Chondrocyte proliferationdefinition[GO:0035988] silver  
1
  • Ortholog Compara
Craniofacial suture morphogenesisdefinition[GO:0097094] silver  
1
  • Ortholog Compara
Embryonic cranial skeleton morphogenesisdefinition[GO:0048701] silver  
1
  • Ortholog Compara
Endochondral ossificationdefinition[GO:0001958] silver  
1
  • Ortholog Compara
Endodermal cell differentiationdefinition[GO:0035987]  
1
  • UniProtKB
Endothelial cell proliferationdefinition[GO:0001935] silver  
1
  • Ortholog Compara
Lung developmentdefinition[GO:0030324] silver  
1
  • Ortholog Compara
Male gonad developmentdefinition[GO:0008584] silver  
1
  • Ortholog Compara
Negative regulation of focal adhesion assemblydefinition[GO:0051895] silver  
1
  • Ortholog Compara
Ovarian follicle developmentdefinition[GO:0001541] silver  
1
  • Ortholog Compara
Positive regulation of cell growthdefinition[GO:0030307]  
1
  • UniProtKB
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • UniProtKB
Positive regulation of peptidase activitydefinition[GO:0010952] silver  
1
  • Ortholog Compara
Proteolysisdefinition[GO:0006508]  
1
  • ParkinsonsUK-UCL
Regulation of transcription, DNA-templateddefinition[GO:0006355] silver  
1
  • Ortholog Compara
Response to estrogendefinition[GO:0043627] silver  
1
  • Ortholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
1
  • Ortholog Compara
Response to mechanical stimulusdefinition[GO:0009612] silver  
1
  • Ortholog Compara
Response to oxidative stressdefinition[GO:0006979] silver  
1
  • Ortholog Compara
Tissue remodelingdefinition[GO:0048771] silver  
1
  • Ortholog Compara
Zymogen activationdefinition[GO:0031638] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.24.80: Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn-|-Leu-38. Other bonds hydrolyzed include 35-Gly-|-Ile-36 in the propeptide of collagenase 3, and 341-Asn-|-Phe-342, 441-Asp-|-Leu-442 and 354-Gln-|-Thr-355 in the aggrecan interglobular domain.  
1
  • UniProtKB
It requires the following cofactors
 Zn(2+) : Binds 1 zinc ion per subunit.  
1
  • UniProtKB
 Ca(2+)  
1
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
GnRH signaling pathway  hsa04912+4323  
According to Reactome, this protein belongs to the following pathways:
Activation of Matrix Metalloproteinases  REACT_118682  
Collagen degradation  REACT_150401  
Degradation of the extracellular matrix  REACT_118572  
 
More information is available from:
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MMP14
GenomeRNAi: 4323
PRO: PR:P50281