PPOX - Protoporphyrinogen oxidase - human protein (Function)
 
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PPOX »  Protoporphyrinogen oxidase   [ EC 1.3.3.4 ]  (PPO)
 
Gene name:  PPOX
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.  
  • CuratedUniProtKB
GO molecular function 
Flavin adenine dinucleotide bindingdefinition[GO:0050660]  
1
  • TASUniProtKB
Oxygen-dependent protoporphyrinogen oxidase activitydefinition[GO:0004729]  
1
  • IDAUniProtKB
GO biological process 
Heme biosynthetic processdefinition[GO:0006783]  
1
  • IDAUniProtKB
Oxidation-reduction processdefinition[GO:0055114]  
1
  • IDAUniProtKB
Porphyrin-containing compound biosynthetic processdefinition[GO:0006779]  
1
  • IDAUniProtKB
Protoporphyrinogen IX biosynthetic processdefinition[GO:0006782]  
  • IEAUniPathway
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.3.3.4: Protoporphyrinogen-IX + 3 O(2) protoporphyrin-IX + 3 H(2)O(2).  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 FAD per subunit.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+5498  
Porphyrin and chlorophyll metabolism  hsa00860+5498  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Biological process 
Heme biosynthesis  definition   [KW-0350]
Porphyrin biosynthesis  definition   [KW-0627]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P50336
Other
GeneWiki: PPOX
GenomeRNAi: 5498
PRO: PR:P50336