EMD - Emerin - human protein (Function)
 
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Protein
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References

 
EMD »  Emerin
 
Gene name:  EMD
Entry whose protein(s) existence is based on evidence at protein level
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1 92 1
GENE REF ISO

Function

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Overview 
Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C.  
5
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
1
  • IDAUniProtKB
Beta-tubulin bindingdefinition[GO:0048487]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
7
  • IPIIntAct
  • IPIUniProtKB
GO biological process 
Cellular response to growth factor stimulusdefinition[GO:0071363]  
1
  • IMPBHF-UCL
Muscle contractiondefinition[GO:0006936]  
1
  • TASPINC
Muscle organ developmentdefinition[GO:0007517]  
2
  • TASPINC
Negative regulation of catenin import into nucleusdefinition[GO:0035414]  
1
  • IMPBHF-UCL
Negative regulation of fibroblast proliferationdefinition[GO:0048147]  
1
  • IMPBHF-UCL
Positive regulation of protein export from nucleusdefinition[GO:0046827]  
1
  • IMPBHF-UCL
Regulation of canonical Wnt signaling pathwaydefinition[GO:0060828]  
1
  • IMPBHF-UCL
Skeletal muscle cell differentiationdefinition[GO:0035914] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Arrhythmogenic right ventricular cardiomyopathy (ARVC)  hsa05412+2010  
Dilated cardiomyopathy  hsa05414+2010  
Hypertrophic cardiomyopathy (HCM)  hsa05410+2010  
According to Reactome, this protein belongs to the following pathways:
Cell Cycle  REACT_115566  
Mitotic M-M/G1 phases  REACT_21300  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Emerin
GenomeRNAi: 2010
PRO: PR:P50402