HTR6 - 5-hydroxytryptamine receptor 6 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
HTR6 »  5-hydroxytryptamine receptor 6  (5-HT6)
 
Protein also known as:  Serotonin receptor 6.
Gene name:  HTR6
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 40 1
GENE REF ISO

Function

 show evidences
Overview 
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs.  
  • CuratedUniProtKB
GO molecular function 
Histamine receptor activitydefinition[GO:0004969]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Serotonin receptor activitydefinition[GO:0004993] silver  
  • IEAInterPro 2 GO
GO biological process 
Brain developmentdefinition[GO:0007420] silver  
  • IEAOrtholog Compara
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerdefinition[GO:0007187] silver  
  • IEAOrtholog Compara
Learningdefinition[GO:0007612] silver  
  • IEAOrtholog Compara
Long-term synaptic potentiationdefinition[GO:0060291] silver  
  • IEAOrtholog Compara
Negative regulation of acetylcholine secretion, neurotransmissiondefinition[GO:0014058] silver  
  • IEAOrtholog Compara
Negative regulation of gamma-aminobutyric acid secretiondefinition[GO:0014053] silver  
  • IEAOrtholog Compara
Negative regulation of glutamate secretiondefinition[GO:0014050] silver  
  • IEAOrtholog Compara
Positive regulation of dopamine secretiondefinition[GO:0033603] silver  
  • IEAOrtholog Compara
Positive regulation of gamma-aminobutyric acid secretiondefinition[GO:0014054] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to estradioldefinition[GO:0032355] silver  
  • IEAOrtholog Compara
Serotonin receptor signaling pathwaydefinition[GO:0007210] silver  
  • IEAOrtholog Compara
Synaptic transmissiondefinition[GO:0007268]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+3362  
Neuroactive ligand-receptor interaction  hsa04080+3362  
According to Reactome, this protein belongs to the following pathways:
G alpha (s) signalling events  REACT_19327  
Serotonin receptors  REACT_17064  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: 5-HT6_receptor
GenomeRNAi: 3362
PRO: PR:P50406
Chemistry
GuidetoPHARMACOLOGY: 11