CSRP3 - Cysteine and glycine-rich protein 3 - human protein (Function)
 
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CSRP3 »  Cysteine and glycine-rich protein 3
 
Protein also known as:  LIM domain protein, cardiac.
Gene name:  CSRP3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Positive regulator of myogenesis. Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation (By similarity).  
1
  • UniProtKB
GO molecular function 
Actinin bindingdefinition[GO:0042805]  
1
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
3
  • IntAct
  • UniProtKB
Structural constituent of muscledefinition[GO:0008307]  
1
  • BHF-UCL
Telethonin bindingdefinition[GO:0031433]  
2
  • BHF-UCL
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Cardiac muscle contractiondefinition[GO:0060048]  
1
  • BHF-UCL
Cardiac muscle hypertrophydefinition[GO:0003300]  
1
  • BHF-UCL
Cardiac muscle tissue developmentdefinition[GO:0048738]  
1
  • Ortholog Curator
Cardiac myofibril assemblydefinition[GO:0055003]  
1
  • BHF-UCL
Cellular calcium ion homeostasisdefinition[GO:0006874]  
1
  • Ortholog Curator
Detection of muscle stretchdefinition[GO:0035995]  
1
  • BHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • MGI
Protein localization to organelledefinition[GO:0033365]  
1
  • BHF-UCL
Regulation of the force of heart contractiondefinition[GO:0002026]  
1
  • Ortholog Curator
Skeletal muscle tissue developmentdefinition[GO:0007519]  
1
  • PINC
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Myogenesis  definition   [KW-0517]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CSRP3
GenomeRNAi: 8048
PRO: PR:P50461