ASCL1 - Achaete-scute homolog 1 - human protein (Function)
 
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Protein
Gene
References

 
ASCL1 »  Achaete-scute homolog 1
 
Gene name:  ASCL1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transcription factor that controls transcriptional expression of its target genes by binding to the E box (5'-CANNTG-3'). Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation. Essential for the generation of olfactory and autonomic neurons (By similarity).  
  • CuratedUniProtKB
GO molecular function 
bHLH transcription factor bindingdefinition[GO:0043425]  
2
  • IPIUniProtKB
DNA bindingdefinition[GO:0003677]  
  • ISSOrtholog Curator
Double-stranded DNA bindingdefinition[GO:0003690] silver  
  • IEAOrtholog Compara
E-box bindingdefinition[GO:0070888]  
2
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAOrtholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • IDAUniProtKB
Transcription factor binding transcription factor activitydefinition[GO:0000989]  
  • ISSOrtholog Curator
GO biological process 
Adrenal chromaffin cell differentiationdefinition[GO:0061104] silver  
  • IEAOrtholog Compara
Carotid body glomus cell differentiationdefinition[GO:0061103] silver  
  • IEAOrtholog Compara
Cellular response to magnetismdefinition[GO:0071259] silver  
  • IEAOrtholog Compara
Central nervous system neuron developmentdefinition[GO:0021954] silver  
  • IEAOrtholog Compara
Cerebral cortex developmentdefinition[GO:0021987] silver  
  • IEAOrtholog Compara
Cerebral cortex GABAergic interneuron differentiationdefinition[GO:0021892]  
1
  • IEPUniProtKB
Lung epithelial cell differentiationdefinition[GO:0060487]  
1
  • NASUniProtKB
Lung neuroendocrine cell differentiationdefinition[GO:0061100] silver  
  • IEAOrtholog Compara
Musculoskeletal movement, spinal reflex actiondefinition[GO:0050883] silver  
  • IEAOrtholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • IMPUniProtKB
Negative regulation of neuron differentiationdefinition[GO:0045665]  
1
  • IDAUniProtKB
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IDAUniProtKB
Neuroblast fate determinationdefinition[GO:0007400] silver  
  • IEAOrtholog Compara
Neuroblast proliferationdefinition[GO:0007405] silver  
  • IEAOrtholog Compara
Neurogenesisdefinition[GO:0022008]  
1
  • IDAUniProtKB
Neuron fate specificationdefinition[GO:0048665] silver  
  • IEAOrtholog Compara
Neuron migrationdefinition[GO:0001764] silver  
  • IEAOrtholog Compara
Noradrenergic neuron developmentdefinition[GO:0003358]  
  • ISSOrtholog Curator
Noradrenergic neuron fate commitmentdefinition[GO:0003359]  
1
  • IMPUniProtKB
Notch signaling pathwaydefinition[GO:0007219]  
1
  • IDAUniProtKB
Olfactory pit developmentdefinition[GO:0060166] silver  
  • IEAOrtholog Compara
Oligodendrocyte developmentdefinition[GO:0014003] silver  
  • IEAOrtholog Compara
Positive regulation of cell cycledefinition[GO:0045787] silver  
  • IEAOrtholog Compara
Positive regulation of neural precursor cell proliferationdefinition[GO:2000179] silver  
  • IEAOrtholog Compara
Positive regulation of neurogenesisdefinition[GO:0050769] silver  
  • IEAOrtholog Compara
Positive regulation of neuron apoptotic processdefinition[GO:0043525] silver  
  • IEAOrtholog Compara
Positive regulation of neuron differentiationdefinition[GO:0045666]  
  • ISSOrtholog Curator
Positive regulation of Notch signaling pathwaydefinition[GO:0045747] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDAUniProtKB
Regulation of gene expressiondefinition[GO:0010468]  
  • ISSOrtholog Curator
Regulation of timing of subpallium neuron differentiationdefinition[GO:0060165] silver  
  • IEAOrtholog Compara
Response to epidermal growth factordefinition[GO:0070849] silver  
  • IEAOrtholog Compara
Response to folic aciddefinition[GO:0051593] silver  
  • IEAOrtholog Compara
Response to lithium iondefinition[GO:0010226] silver  
  • IEAOrtholog Compara
Response to retinoic aciddefinition[GO:0032526]  
1
  • IEPUniProtKB
Spinal cord association neuron differentiationdefinition[GO:0021527] silver  
  • IEAOrtholog Compara
Spinal cord oligodendrocyte cell fate specificationdefinition[GO:0021530] silver  
  • IEAOrtholog Compara
Stomach neuroendocrine cell differentiationdefinition[GO:0061102] silver  
  • IEAOrtholog Compara
Subpallium neuron fate commitmentdefinition[GO:0060163] silver  
  • IEAOrtholog Compara
Sympathetic ganglion developmentdefinition[GO:0061549]  
  • ISSOrtholog Curator
Sympathetic nervous system developmentdefinition[GO:0048485]  
1
  • NASUniProtKB
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Ventral spinal cord interneuron fate commitmentdefinition[GO:0060579]  
  • ISSOrtholog Curator
Vestibular nucleus developmentdefinition[GO:0021750] silver  
  • IEAOrtholog Compara
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Neurogenesis  definition   [KW-0524]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ASCL1
GenomeRNAi: 429
PRO: PR:P50553