ASCL1 - Achaete-scute homolog 1 - human protein (Function)
 
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ASCL1 »  Achaete-scute homolog 1  (ASH-1)
 
Protein also known as:  Class A basic helix-loop-helix protein 46 (bHLHa46).
Gene name:  ASCL1
Entry whose protein(s) existence is based on evidence at protein level
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1 58 1
GENE REF ISO

Function

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Overview 
Transcription factor that controls transcriptional expression of its target genes by binding to the E box (5'-CANNTG-3'). Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation. Essential for the generation of olfactory and autonomic neurons (By similarity).  
1
  • UniProtKB
GO molecular function 
bHLH transcription factor bindingdefinition[GO:0043425]  
2
  • UniProtKB
Chromatin bindingdefinition[GO:0003682] silver  
1
  • Ortholog Compara
DNA bindingdefinition[GO:0003677]  
1
  • Ortholog Curator
Double-stranded DNA bindingdefinition[GO:0003690] silver  
1
  • Ortholog Compara
E-box bindingdefinition[GO:0070888]  
2
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Protein homodimerization activitydefinition[GO:0042803] silver  
1
  • Ortholog Compara
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
1
  • NTNU_SB
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptiondefinition[GO:0001078]  
1
  • NTNU_SB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • UniProtKB
Transcription factor binding transcription factor activitydefinition[GO:0000989]  
1
  • Ortholog Curator
GO biological process 
Adrenal chromaffin cell differentiationdefinition[GO:0061104] silver  
1
  • Ortholog Compara
Carotid body glomus cell differentiationdefinition[GO:0061103] silver  
1
  • Ortholog Compara
Cell maturationdefinition[GO:0048469] silver  
1
  • Ortholog Compara
Cellular response to magnetismdefinition[GO:0071259] silver  
1
  • Ortholog Compara
Central nervous system neuron developmentdefinition[GO:0021954] silver  
1
  • Ortholog Compara
Cerebral cortex developmentdefinition[GO:0021987] silver  
1
  • Ortholog Compara
Cerebral cortex GABAergic interneuron differentiationdefinition[GO:0021892]  
1
  • UniProtKB
Commitment of neuronal cell to specific neuron type in forebraindefinition[GO:0021902] silver  
1
  • Ortholog Compara
Lung epithelial cell differentiationdefinition[GO:0060487]  
1
  • UniProtKB
Lung neuroendocrine cell differentiationdefinition[GO:0061100] silver  
1
  • Ortholog Compara
Musculoskeletal movement, spinal reflex actiondefinition[GO:0050883] silver  
1
  • Ortholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • UniProtKB
Negative regulation of neuron differentiationdefinition[GO:0045665]  
1
  • UniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • NTNU_SB
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • UniProtKB
Neuroblast fate determinationdefinition[GO:0007400] silver  
1
  • Ortholog Compara
Neuroblast proliferationdefinition[GO:0007405] silver  
1
  • Ortholog Compara
Neurogenesisdefinition[GO:0022008]  
1
  • UniProtKB
Neuron fate specificationdefinition[GO:0048665] silver  
1
  • Ortholog Compara
Neuron migrationdefinition[GO:0001764] silver  
1
  • Ortholog Compara
Noradrenergic neuron developmentdefinition[GO:0003358]  
1
  • Ortholog Curator
Noradrenergic neuron fate commitmentdefinition[GO:0003359]  
1
  • UniProtKB
Notch signaling pathwaydefinition[GO:0007219]  
1
  • UniProtKB
Olfactory pit developmentdefinition[GO:0060166] silver  
1
  • Ortholog Compara
Oligodendrocyte developmentdefinition[GO:0014003] silver  
1
  • Ortholog Compara
Positive regulation of cell cycledefinition[GO:0045787] silver  
1
  • Ortholog Compara
Positive regulation of neural precursor cell proliferationdefinition[GO:2000179] silver  
1
  • Ortholog Compara
Positive regulation of neuron apoptotic processdefinition[GO:0043525] silver  
1
  • Ortholog Compara
Positive regulation of neuron differentiationdefinition[GO:0045666]  
1
  • Ortholog Curator
Positive regulation of Notch signaling pathwaydefinition[GO:0045747] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • UniProtKB
Regulation of epithelial cell differentiationdefinition[GO:0030856] silver  
1
  • Ortholog Compara
Regulation of gene expressiondefinition[GO:0010468]  
1
  • Ortholog Curator
Regulation of mitotic cell cycledefinition[GO:0007346] silver  
1
  • Ortholog Compara
Regulation of timing of subpallium neuron differentiationdefinition[GO:0060165] silver  
1
  • Ortholog Compara
Response to epidermal growth factordefinition[GO:0070849] silver  
1
  • Ortholog Compara
Response to folic aciddefinition[GO:0051593] silver  
1
  • Ortholog Compara
Response to lithium iondefinition[GO:0010226] silver  
1
  • Ortholog Compara
Response to retinoic aciddefinition[GO:0032526]  
1
  • UniProtKB
Spinal cord association neuron differentiationdefinition[GO:0021527] silver  
1
  • Ortholog Compara
Spinal cord oligodendrocyte cell fate specificationdefinition[GO:0021530] silver  
1
  • Ortholog Compara
Stomach neuroendocrine cell differentiationdefinition[GO:0061102] silver  
1
  • Ortholog Compara
Subpallium neuron fate commitmentdefinition[GO:0060163] silver  
1
  • Ortholog Compara
Sympathetic ganglion developmentdefinition[GO:0061549]  
1
  • Ortholog Curator
Sympathetic nervous system developmentdefinition[GO:0048485]  
1
  • UniProtKB
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
Ventral spinal cord interneuron fate commitmentdefinition[GO:0060579]  
1
  • Ortholog Curator
Vestibular nucleus developmentdefinition[GO:0021750] silver  
1
  • Ortholog Compara
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Neurogenesis  definition   [KW-0524]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ASCL1
GenomeRNAi: 429
PRO: PR:P50553