ATP1A2 - Sodium/potassium-transporting ATPase subunit alpha-2 - human protein (Function)
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ATP1A2 »  Sodium/potassium-transporting ATPase subunit alpha-2   [ EC ]  (Na(+)/K(+) ATPase alpha-2 subunit)
Protein also known as:  Sodium pump subunit alpha-2.
Gene name:  ATP1A2
Entry whose protein(s) existence is based on evidence at protein level
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This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the p-type atpase (p-atpase) superfamily  3.A.3.1.1  
GO molecular function 
ATP bindingdefinition[GO:0005524] silver  
  • IEAOrtholog Compara
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Sodium:potassium-exchanging ATPase activitydefinition[GO:0005391]  
  • IMPUniProtKB
GO biological process 
Adult locomotory behaviordefinition[GO:0008344] silver  
  • IEAOrtholog Compara
ATP biosynthetic processdefinition[GO:0006754] silver  
  • IEAInterPro 2 GO
ATP hydrolysis coupled proton transportdefinition[GO:0015991] silver  
  • IEAOrtholog Compara
Cellular response to mechanical stimulusdefinition[GO:0071260] silver  
  • IEAOrtholog Compara
Locomotiondefinition[GO:0040011] silver  
  • IEAOrtholog Compara
Negative regulation of cytosolic calcium ion concentrationdefinition[GO:0051481] silver  
  • IEAOrtholog Compara
Negative regulation of heart contractiondefinition[GO:0045822] silver  
  • IEAOrtholog Compara
Negative regulation of striated muscle contractiondefinition[GO:0045988] silver  
  • IEAOrtholog Compara
Neurotransmitter uptakedefinition[GO:0001504] silver  
  • IEAOrtholog Compara
Potassium ion transportdefinition[GO:0006813]  
  • NASUniProtKB
Regulation of blood pressuredefinition[GO:0008217] silver  
  • IEAOrtholog Compara
Regulation of cardiac muscle cell contractiondefinition[GO:0086004] silver  
  • IEAOrtholog Compara
Regulation of respiratory gaseous exchange by neurological system processdefinition[GO:0002087] silver  
  • IEAOrtholog Compara
Regulation of smooth muscle contractiondefinition[GO:0006940] silver  
  • IEAOrtholog Compara
Regulation of striated muscle contractiondefinition[GO:0006942]  
  • NASUniProtKB
Regulation of the force of heart contractiondefinition[GO:0002026] silver  
  • IEAOrtholog Compara
Regulation of vasoconstrictiondefinition[GO:0019229] silver  
  • IEAOrtholog Compara
Response to nicotinedefinition[GO:0035094] silver  
  • IEAOrtholog Compara
Sodium ion transmembrane transportdefinition[GO:0035725]  
  • IEAEC 2 GO
  • IEAOrtholog Compara
Sodium ion transportdefinition[GO:0006814]  
  • NASUniProtKB
Visual learningdefinition[GO:0008542] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC ATP + H(2)O + Na(+)(In) + K(+)(Out) ADP + phosphate + Na(+)(Out) + K(+)(In).  
  • CuratedUniProtKB
According to KEGG, this protein belongs to the following pathways:
Aldosterone-regulated sodium reabsorption  hsa04960+477  
Bile secretion  hsa04976+477  
Carbohydrate digestion and absorption  hsa04973+477  
Cardiac muscle contraction  hsa04260+477  
Endocrine and other factor-regulated calcium reabsorption  hsa04961+477  
Gastric acid secretion  hsa04971+477  
Mineral absorption  hsa04978+477  
Pancreatic secretion  hsa04972+477  
Protein digestion and absorption  hsa04974+477  
Proximal tubule bicarbonate reclamation  hsa04964+477  
Salivary secretion  hsa04970+477  
According to Reactome, this protein belongs to the following pathway:
Ion transport by P-type ATPases  REACT_25149  


Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Sodium transport  definition   [KW-0739]
Sodium/potassium transport  definition   [KW-0740]
Transport  definition   [KW-0813]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: ATP1A2
GenomeRNAi: 477
PRO: PR:P50993