ATP1A2 - Sodium/potassium-transporting ATPase subunit alpha-2 - human protein (Function)
 
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ATP1A2 »  Sodium/potassium-transporting ATPase subunit alpha-2   [ EC 3.6.3.9 ]  (Na(+)/K(+) ATPase alpha-2 subunit)
 
Protein also known as:  Sodium pump subunit alpha-2.
Gene name:  ATP1A2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients.  
1
  • UniProtKB
According to TCDB this is a transporter from family:
the p-type atpase (p-atpase) superfamily  3.A.3.1.1  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Chaperone bindingdefinition[GO:0051087]  
1
  • BHF-UCL
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Sodium:potassium-exchanging ATPase activitydefinition[GO:0005391]  
2
  • UniProtKB
  • BHF-UCL
Steroid hormone bindingdefinition[GO:1990239]  
1
  • BHF-UCL
GO biological process 
Adult locomotory behaviordefinition[GO:0008344] silver  
1
  • Ortholog Compara
ATP hydrolysis coupled proton transportdefinition[GO:0015991] silver  
1
  • Ortholog Compara
Cardiac muscle contractiondefinition[GO:0060048]  
1
  • BHF-UCL
Cell communication by electrical coupling involved in cardiac conductiondefinition[GO:0086064]  
1
  • BHF-UCL
Cellular potassium ion homeostasisdefinition[GO:0030007]  
1
  • BHF-UCL
Cellular response to mechanical stimulusdefinition[GO:0071260] silver  
1
  • Ortholog Compara
Cellular response to steroid hormone stimulusdefinition[GO:0071383]  
1
  • BHF-UCL
Cellular sodium ion homeostasisdefinition[GO:0006883]  
1
  • BHF-UCL
Locomotiondefinition[GO:0040011] silver  
1
  • Ortholog Compara
Membrane depolarization during cardiac muscle cell action potentialdefinition[GO:0086012]  
1
  • BHF-UCL
Metabolic processdefinition[GO:0008152]  
1
  • UniProtKB KW
Negative regulation of calcium ion transmembrane transportdefinition[GO:1903170]  
1
  • Ortholog Curator
Negative regulation of calcium:sodium antiporter activitydefinition[GO:1903280]  
1
  • Ortholog Curator
Negative regulation of cytosolic calcium ion concentrationdefinition[GO:0051481] silver  
1
  • Ortholog Compara
Negative regulation of heart contractiondefinition[GO:0045822] silver  
1
  • Ortholog Compara
Negative regulation of striated muscle contractiondefinition[GO:0045988] silver  
1
  • Ortholog Compara
Neurotransmitter uptakedefinition[GO:0001504] silver  
1
  • Ortholog Compara
Potassium ion importdefinition[GO:0010107]  
1
  • BHF-UCL
Potassium ion transportdefinition[GO:0006813]  
1
  • UniProtKB
Regulation of blood pressuredefinition[GO:0008217] silver  
1
  • Ortholog Compara
Regulation of cardiac muscle cell contractiondefinition[GO:0086004] silver  
1
  • Ortholog Compara
Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium iondefinition[GO:0010881]  
1
  • BHF-UCL
Regulation of respiratory gaseous exchange by neurological system processdefinition[GO:0002087] silver  
1
  • Ortholog Compara
Regulation of smooth muscle contractiondefinition[GO:0006940] silver  
1
  • Ortholog Compara
Regulation of striated muscle contractiondefinition[GO:0006942]  
1
  • UniProtKB
Regulation of the force of heart contractiondefinition[GO:0002026] silver  
1
  • Ortholog Compara
Regulation of vasoconstrictiondefinition[GO:0019229] silver  
1
  • Ortholog Compara
Relaxation of cardiac muscledefinition[GO:0055119]  
1
  • BHF-UCL
Response to glycosidedefinition[GO:1903416]  
2
  • BHF-UCL
  • Ortholog Curator
Response to nicotinedefinition[GO:0035094] silver  
1
  • Ortholog Compara
Sodium ion export from celldefinition[GO:0036376]  
1
  • BHF-UCL
Sodium ion transportdefinition[GO:0006814]  
1
  • UniProtKB
Visual learningdefinition[GO:0008542] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.3.9: ATP + H(2)O + Na(+)(In) + K(+)(Out) ADP + phosphate + Na(+)(Out) + K(+)(In).  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Aldosterone-regulated sodium reabsorption  hsa04960+477  
Bile secretion  hsa04976+477  
Carbohydrate digestion and absorption  hsa04973+477  
Cardiac muscle contraction  hsa04260+477  
Endocrine and other factor-regulated calcium reabsorption  hsa04961+477  
Gastric acid secretion  hsa04971+477  
Mineral absorption  hsa04978+477  
Pancreatic secretion  hsa04972+477  
Protein digestion and absorption  hsa04974+477  
Proximal tubule bicarbonate reclamation  hsa04964+477  
Salivary secretion  hsa04970+477  
According to Reactome, this protein belongs to the following pathway:
Ion transport by P-type ATPases  REACT_25149  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Sodium transport  definition   [KW-0739]
Sodium/potassium transport  definition   [KW-0740]
Transport  definition   [KW-0813]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATP1A2
GenomeRNAi: 477
PRO: PR:P50993