GZMM - Granzyme M - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
GZMM »  Granzyme M   [ EC 3.4.21.- ]
 
Protein also known as:  Natural killer cell granular protease.
Gene name:  GZMM
Family name: Peptidase S1 » Granzyme
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 21 1
GENE REF ISO

Function

 show evidences
Overview 
Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.  
2
  • CuratedUniProtKB
GO molecular function 
Serine-type endopeptidase activitydefinition[GO:0004252] silver  
  • IEAInterPro 2 GO
Serine-type peptidase activitydefinition[GO:0008236]  
1
  • TASPINC
GO biological process 
Apoptotic processdefinition[GO:0006915]  
  • IEAUniProtKB KW
Cytolysisdefinition[GO:0019835] silver  
  • IEAOrtholog Compara
Innate immune responsedefinition[GO:0045087]  
  • IEAUniProtKB KW
Enzymatic activity 
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Cytolysis  definition   [KW-0204]
Immunity  definition   [KW-0391]
Innate immunity  definition   [KW-0399]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GZMM
GenomeRNAi: 3004
PRO: PR:P51124