RAB7A - Ras-related protein Rab-7a - human protein (Function)
 
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References

 
RAB7A »  Ras-related protein Rab-7a
 
Gene name:  RAB7A
Family name: Small GTPase » Rab
Entry whose protein(s) existence is based on evidence at protein level
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1 82 1
GENE REF ISO

Function

 show evidences
Overview 
Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA. Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation.  
4
  • CuratedUniProtKB
GO molecular function 
GDP bindingdefinition[GO:0019003]  
1
  • IDABHF-UCL
GTP bindingdefinition[GO:0005525]  
1
  • IDABHF-UCL
GTPase activitydefinition[GO:0003924]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
6
  • IPIUniProtKB
  • IPIBHF-UCL
Rac GTPase bindingdefinition[GO:0048365] silver  
  • IEAOrtholog Compara
GO biological process 
Bone resorptiondefinition[GO:0045453] silver  
  • IEAOrtholog Compara
Early endosome to late endosome transportdefinition[GO:0045022]  
1
  • IMPUniProtKB
Endocytosisdefinition[GO:0006897]  
1
  • TASPINC
Endosome to lysosome transportdefinition[GO:0008333]  
1
  • IMPBHF-UCL
Epidermal growth factor catabolic processdefinition[GO:0007174]  
1
  • IMPBHF-UCL
GTP catabolic processdefinition[GO:0006184]  
2
  • IDAGOC
Phagosome acidificationdefinition[GO:0090383]  
1
  • IMPUniProtKB
Phagosome maturationdefinition[GO:0090382]  
1
  • TASUniProtKB
Phagosome-lysosome fusiondefinition[GO:0090385]  
1
  • IMPUniProtKB
Protein targeting to lysosomedefinition[GO:0006622]  
1
  • IMPBHF-UCL
Protein transportdefinition[GO:0015031]  
1
  • TASUniProtKB
Small GTPase mediated signal transductiondefinition[GO:0007264] silver  
  • IEAInterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathways:
Amoebiasis  hsa05146+7879  
Endocytosis  hsa04144+7879  
Phagosome  hsa04145+7879  
Salmonella infection  hsa05132+7879  
Tuberculosis  hsa05152+7879  
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Biological process 
Protein transport  definition   [KW-0653]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RAB7A
GenomeRNAi: 7879
PRO: PR:P51149