RAB13 - Ras-related protein Rab-13 - human protein (Function)
 
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RAB13 »  Ras-related protein Rab-13
 
Protein also known as:  Cell growth-inhibiting gene 4 protein.
Gene name:  RAB13
Family name: Small GTPase » Rab
Entry whose protein(s) existence is based on evidence at protein level
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1 31 1
GENE REF ISO

Function

 show evidences
Overview 
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis.  
6
  • CuratedUniProtKB
GO molecular function 
GTP bindingdefinition[GO:0005525]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
6
  • IPIIntAct
  • IPIUniProtKB
Protein kinase A catalytic subunit bindingdefinition[GO:0034236] silver  
  • IEAOrtholog Compara
GO biological process 
Cellular response to insulin stimulusdefinition[GO:0032869]  
  • ISSOrtholog Curator
Cortical actin cytoskeleton organizationdefinition[GO:0030866]  
  • ISSOrtholog Curator
Endocytic recyclingdefinition[GO:0032456]  
1
  • IMPUniProtKB
Endosomal transportdefinition[GO:0016197]  
1
  • IMPUniProtKB
Endothelial cell chemotaxisdefinition[GO:0035767]  
  • ISSOrtholog Curator
Establishment of protein localization to plasma membranedefinition[GO:0090002]  
1
  • IMPUniProtKB
Establishment of Sertoli cell barrierdefinition[GO:0097368]  
  • ISSOrtholog Curator
Neuron projection developmentdefinition[GO:0031175]  
1
  • IMPUniProtKB
Protein kinase A signalingdefinition[GO:0010737]  
1
  • IMPUniProtKB
Protein transportdefinition[GO:0015031]  
  • IEAUniProtKB KW
Small GTPase mediated signal transductiondefinition[GO:0007264] silver  
  • IEAInterPro 2 GO
Tight junction assemblydefinition[GO:0070830]  
2
  • IMPUniProtKB
Trans-Golgi network to recycling endosome transportdefinition[GO:0044795]  
  • ISSOrtholog Curator
Enzymatic activity 
It is regulated in the following manner
Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP). That Rab may be activated by DENND1C, a guanine exchange factor. Activated in response to insulin.  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Tight junction  hsa04530+5872  
According to Reactome, this protein belongs to the following pathway:
Translocation of GLUT4 to the plasma membrane  REACT_147867  
 

Keywords

Biological process 
Protein transport  definition   [KW-0653]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RAB13
GenomeRNAi: 5872
PRO: PR:P51153