SCNN1G - Amiloride-sensitive sodium channel subunit gamma - human protein (Function)
 
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SCNN1G »  Amiloride-sensitive sodium channel subunit gamma
 
Protein also known as:  Nonvoltage-gated sodium channel 1 subunit gamma.
Gene name:  SCNN1G
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 82 1
GENE REF ISO

Function

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Overview 
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.  
3
  • UniProtKB
According to TCDB this is a transporter from family:
the epithelial na(+) channel (enac) family  1.A.6.1.1  
GO molecular function 
Ion channel activitydefinition[GO:0005216] silver  
1
  • CACAO
Contributes to ligand-gated sodium channel activitydefinition[GO:0015280]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • UniProtKB
Sodium channel activitydefinition[GO:0005272]  
1
  • PINC
WW domain bindingdefinition[GO:0050699]  
1
  • BHF-UCL
GO biological process 
Excretiondefinition[GO:0007588]  
1
  • PINC
Multicellular organismal water homeostasisdefinition[GO:0050891]  
1
  • UniProtKB
Response to stimulusdefinition[GO:0050896]  
1
  • UniProtKB KW
Sensory perception of tastedefinition[GO:0050909]  
1
  • UniProtKB KW
Sodium ion homeostasisdefinition[GO:0055078]  
1
  • UniProtKB
Sodium ion transmembrane transportdefinition[GO:0035725]  
1
  • UniProtKB
Sodium ion transportdefinition[GO:0006814]  
1
  • PINC
Enzymatic activity 
It is regulated in the following manner
Activated by WNK1, WNK2, WNK3 and WNK4.  
2
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Aldosterone-regulated sodium reabsorption  hsa04960+6340  
Taste transduction  hsa04742+6340  
According to Reactome, this protein belongs to the following pathway:
Stimuli-sensing channels  REACT_160189  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Sensory transduction  definition   [KW-0716]
Sodium transport  definition   [KW-0739]
Taste  definition   [KW-0919]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Sodium channel  definition   [KW-0894]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SCNN1G
GenomeRNAi: 6340
PRO: PR:P51170