BLK - Tyrosine-protein kinase Blk - human protein (Function)
 
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BLK »  Tyrosine-protein kinase Blk   [ EC 2.7.10.2 ]
 
Protein also known as:  B lymphocyte kinase.
Gene name:  BLK
Entry whose protein(s) existence is based on evidence at protein level
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Function

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Overview 
Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207'. Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C. With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation. Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation. In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose.  
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  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Non-membrane spanning protein tyrosine kinase activitydefinition[GO:0004715]  
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  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
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  • IPIIntAct
Protein tyrosine kinase activitydefinition[GO:0004713]  
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  • TASPINC
GO biological process 
B cell receptor signaling pathwaydefinition[GO:0050853]  
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  • IDAUniProtKB
Intracellular signal transductiondefinition[GO:0035556]  
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  • TASPINC
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
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  • TASGOC
  • IEAEC 2 GO
  • IEAUniProtKB KW
  • IEAInterPro 2 GO
Positive regulation of insulin secretiondefinition[GO:0032024]  
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  • IMPUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.2: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
  • CuratedUniProtKB
It is regulated in the following manner
Antibody-mediated surface engagement of the B-cell antigen receptor (BCR) which results in the phosphorylation of BLK on tyrosine residues, stimulates the enzymatic activity (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers  REACT_118700  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Tyrosine-protein_kinase_BLK
GenomeRNAi: 640
PRO: PR:P51451
Chemistry
GuidetoPHARMACOLOGY: 1940