MMP16 - Matrix metalloproteinase-16 - human protein (Function)
 
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MMP16 »  Matrix metalloproteinase-16   [ EC 3.4.24.- ]  (MMP-16)
 
Protein also known as:  Membrane-type matrix metalloproteinase 3 (MTMMP3).
Gene name:  MMP16
Family name: Peptidase M10A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 31 2
GENE REF ISO

Function

 show evidences
Overview 
Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels.  
1
  • CuratedUniProtKB
Isoform  Short   Cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.  
1
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Enzyme activator activitydefinition[GO:0008047]  
1
  • TASPINC
Metalloendopeptidase activitydefinition[GO:0004222] silver  
  • IEAInterPro 2 GO
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Collagen catabolic processdefinition[GO:0030574]  
  • IEAUniProtKB KW
Positive regulation of catalytic activitydefinition[GO:0043085]  
1
  • TASGOC
Enzymatic activity 
It requires the following cofactors
Binds 1 zinc ion per subunit (By similarity).  
  • CuratedUniProtKB
Calcium (By similarity).  
  • CuratedUniProtKB
It is regulated in the following manner
TIMP-2 shows little inhibitory activity compared to TIMP-1. TIMP-1 seems to have less binding affinity than TIMP-2 for the short isoform.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Extracellular matrix organization  REACT_118779  
 

Keywords

Biological process 
Collagen degradation  definition   [KW-0177]
Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MMP16
GenomeRNAi: 4325
PRO: PR:P51512