MMP16 - Matrix metalloproteinase-16 - human protein (Function)
 
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MMP16 »  Matrix metalloproteinase-16   [ EC 3.4.24.- ]  (MMP-16)
 
Protein also known as:  Membrane-type-3 matrix metalloproteinase (MT3MMP).
Gene name:  MMP16
Family name: Peptidase M10A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 33 2
GENE REF ISO

Function

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Overview 
Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels.  
1
  • UniProtKB
Isoform  Short   Cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.  
2
  • UniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
1
  • InterPro 2 GO
Enzyme activator activitydefinition[GO:0008047]  
1
  • PINC
Metalloendopeptidase activitydefinition[GO:0004222] silver  
1
  • InterPro 2 GO
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Chondrocyte proliferationdefinition[GO:0035988] silver  
1
  • Ortholog Compara
Collagen catabolic processdefinition[GO:0030574] silver  
1
  • Ortholog Compara
Craniofacial suture morphogenesisdefinition[GO:0097094] silver  
1
  • Ortholog Compara
Embryonic cranial skeleton morphogenesisdefinition[GO:0048701] silver  
1
  • Ortholog Compara
Endochondral ossificationdefinition[GO:0001958] silver  
1
  • Ortholog Compara
Positive regulation of catalytic activitydefinition[GO:0043085]  
1
  • GOC
Proteolysisdefinition[GO:0006508]  
1
  • UniProtKB KW
Enzymatic activity 
It requires the following cofactors
 Zn(2+) : Binds 1 zinc ion per subunit.  
1
  • UniProtKB
 Ca(2+)  
1
  • UniProtKB
It is regulated in the following manner
TIMP-2 shows little inhibitory activity compared to TIMP-1. TIMP-1 seems to have less binding affinity than TIMP-2 for the short isoform.  
1
  • UniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Activation of Matrix Metalloproteinases  REACT_118682  
 

Keywords

Biological process 
Collagen degradation  definition   [KW-0177]
Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MMP16
GenomeRNAi: 4325
PRO: PR:P51512