SMARCA2 - Probable global transcription activator SNF2L2 - human protein (Function)
 
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SMARCA2 »  Probable global transcription activator SNF2L2   [ EC 3.6.4.- ]
 
Protein also known as:  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2.
Gene name:  SMARCA2
Family name: SNF2/RAD54 helicase
Entry whose protein(s) existence is based on evidence at protein level
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1 93 2
GENE REF ISO

Function

 show evidences
Overview 
Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).  
1
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
DNA-dependent ATPase activitydefinition[GO:0008094]  
1
  • TASBHF-UCL
Helicase activitydefinition[GO:0004386]  
  • IEAUniProtKB KW
Histone bindingdefinition[GO:0042393] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
6
  • IPIUniProtKB
  • IPIIntAct
  • IPIBHF-UCL
RNA polymerase II transcription coactivator activitydefinition[GO:0001105]  
1
  • IDAUniProtKB
Transcription coactivator activitydefinition[GO:0003713]  
1
  • TASPINC
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • IDAUniProtKB
GO biological process 
Aortic smooth muscle cell differentiationdefinition[GO:0035887] silver  
  • IEAOrtholog Compara
ATP catabolic processdefinition[GO:0006200]  
1
  • TASGOC
Chromatin remodelingdefinition[GO:0006338]  
1
  • TASBHF-UCL
Negative regulation of cell growthdefinition[GO:0030308]  
1
  • IMPBHF-UCL
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • TASBHF-UCL
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IDABHF-UCL
Nervous system developmentdefinition[GO:0007399]  
  • IEAUniProtKB KW
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • TASBHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
2
  • IDAUniProtKB
  • IMPBHF-UCL
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • TASPINC
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • TASPINC
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Neurogenesis  definition   [KW-0524]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Helicase  definition   [KW-0347]
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SMARCA2
GenomeRNAi: 6595
PRO: PR:P51531