SMARCA4 - Transcription activator BRG1 - human protein (Function)
 
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SMARCA4 »  Transcription activator BRG1   [ EC 3.6.4.- ]
 
Protein also known as:  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4.
Gene name:  SMARCA4
Family name: SNF2/RAD54 helicase
Entry whose protein(s) existence is based on evidence at protein level
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1 219 5
GENE REF ISO

Function

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Overview 
Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1.  
4
  • UniProtKB
GO molecular function 
Androgen receptor bindingdefinition[GO:0050681]  
1
  • BHF-UCL
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
DNA polymerase bindingdefinition[GO:0070182]  
1
  • BHF-UCL
DNA-dependent ATPase activitydefinition[GO:0008094]  
1
  • BHF-UCL
Helicase activitydefinition[GO:0004386]  
1
  • UniProtKB KW
Lysine-acetylated histone bindingdefinition[GO:0070577]  
1
  • BHF-UCL
Contributes to nucleosomal DNA bindingdefinition[GO:0031492]  
1
  • UniProtKB
P53 bindingdefinition[GO:0002039]  
1
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
22
  • IntAct
  • UniProtKB
  • BHF-UCL
Protein N-terminus bindingdefinition[GO:0047485]  
1
  • UniProtKB
Contributes to RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
1
  • UniProtKB
Contributes to RNA polymerase II distal enhancer sequence-specific DNA bindingdefinition[GO:0000980]  
1
  • UniProtKB
RNA polymerase II transcription coactivator activitydefinition[GO:0001105]  
1
  • BHF-UCL
Tat protein bindingdefinition[GO:0030957]  
1
  • BHF-UCL
Transcription coactivator activitydefinition[GO:0003713]  
2
  • BHF-UCL
Transcription corepressor activitydefinition[GO:0003714]  
2
  • UniProtKB
  • BHF-UCL
GO biological process 
Aortic smooth muscle cell differentiationdefinition[GO:0035887] silver  
1
  • Ortholog Compara
ATP catabolic processdefinition[GO:0006200]  
1
  • GOC
ATP-dependent chromatin remodelingdefinition[GO:0043044]  
1
  • UniProtKB
Blastocyst growthdefinition[GO:0001832] silver  
1
  • Ortholog Compara
Blastocyst hatchingdefinition[GO:0001835] silver  
1
  • Ortholog Compara
Cell morphogenesisdefinition[GO:0000902] silver  
1
  • Ortholog Compara
Chromatin remodelingdefinition[GO:0006338]  
3
  • BHF-UCL
Definitive erythrocyte differentiationdefinition[GO:0060318] silver  
1
  • Ortholog Compara
DNA methylation on cytosine within a CG sequencedefinition[GO:0010424] silver  
1
  • Ortholog Compara
Embryonic hindlimb morphogenesisdefinition[GO:0035116] silver  
1
  • Ortholog Compara
Embryonic organ morphogenesisdefinition[GO:0048562] silver  
1
  • Ortholog Compara
Epidermis morphogenesisdefinition[GO:0048730] silver  
1
  • Ortholog Compara
Extracellular matrix organizationdefinition[GO:0030198] silver  
1
  • Ortholog Compara
Forebrain developmentdefinition[GO:0030900] silver  
1
  • Ortholog Compara
Glial cell fate determinationdefinition[GO:0007403] silver  
1
  • Ortholog Compara
Heart trabecula formationdefinition[GO:0060347] silver  
1
  • Ortholog Compara
Hindbrain developmentdefinition[GO:0030902] silver  
1
  • Ortholog Compara
Histone H3 acetylationdefinition[GO:0043966] silver  
1
  • Ortholog Compara
Keratinocyte differentiationdefinition[GO:0030216] silver  
1
  • Ortholog Compara
Lens fiber cell developmentdefinition[GO:0070307] silver  
1
  • Ortholog Compara
Liver developmentdefinition[GO:0001889] silver  
1
  • Ortholog Compara
Methylation-dependent chromatin silencingdefinition[GO:0006346] silver  
1
  • Ortholog Compara
Negative regulation of androgen receptor signaling pathwaydefinition[GO:0060766]  
1
  • BHF-UCL
Negative regulation of cell growthdefinition[GO:0030308]  
1
  • BHF-UCL
Negative regulation of G1/S transition of mitotic cell cycledefinition[GO:2000134]  
1
  • BHF-UCL
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • BHF-UCL
Negative regulation of transcription from RNA polymerase II promoter during mitosisdefinition[GO:0007070]  
1
  • BHF-UCL
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
2
  • BHF-UCL
Neural retina developmentdefinition[GO:0003407]  
1
  • BHF-UCL
Nucleosome disassemblydefinition[GO:0006337]  
1
  • BHF-UCL
Positive regulation by host of viral transcriptiondefinition[GO:0043923]  
1
  • BHF-UCL
Positive regulation of DNA bindingdefinition[GO:0043388] silver  
1
  • Ortholog Compara
Positive regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051091]  
2
  • BHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
3
  • BHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • BHF-UCL
Positive regulation of Wnt signaling pathwaydefinition[GO:0030177]  
1
  • BHF-UCL
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • BHF-UCL
Stem cell maintenancedefinition[GO:0019827] silver  
1
  • Ortholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
Vasculogenesisdefinition[GO:0001570] silver  
1
  • Ortholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathways:
formation of the beta-catenin:TCF transactivating complex  REACT_200753  
RMTs methylate histone arginines  REACT_228108  
 

Keywords

Biological process 
Neurogenesis  definition   [KW-0524]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Chromatin regulator  definition   [KW-0156]
Helicase  definition   [KW-0347]
Hydrolase  definition   [KW-0378]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SMARCA4
GenomeRNAi: 6597
PRO: PR:P51532