IDH3G - Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial - human protein (Function)
 
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IDH3G »  Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial   [ EC 1.1.1.41 ]
 
Protein also known as:  Isocitric dehydrogenase subunit gamma.
Gene name:  IDH3G
Entry whose protein(s) existence is based on evidence at protein level
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1 13 2
GENE REF ISO

Function

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GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Isocitrate dehydrogenase (NAD+) activitydefinition[GO:0004449]  
  • ISSOrtholog Curator
Magnesium ion bindingdefinition[GO:0000287] silver  
  • IEAInterPro 2 GO
NAD bindingdefinition[GO:0051287] silver  
  • IEAInterPro 2 GO
GO biological process 
Carbohydrate metabolic processdefinition[GO:0005975]  
1
  • NASPINC
Isocitrate metabolic processdefinition[GO:0006102]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.1.1.41: Isocitrate + NAD(+) 2-oxoglutarate + CO(2) + NADH.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 magnesium or manganese ion per subunit (By similarity).  
  • CuratedUniProtKB
It is regulated in the following manner
Activated by increasing ADP/ATP ratios and by Ca(2+) (By similarity).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Citrate cycle (TCA cycle)  hsa00020+3421  
Metabolic pathways  hsa01100+3421  
According to Reactome, this protein belongs to the following pathways:
Citric acid cycle (TCA cycle)  REACT_1785  
Mitochondrial protein import  REACT_118595  
 
More information is available from:
 

Keywords

Biological process 
Tricarboxylic acid cycle  definition   [KW-0816]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P51553
Other
GeneWiki: IDH3G
GenomeRNAi: 3421
PRO: PR:P51553