BCAP31 - B-cell receptor-associated protein 31 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
BCAP31 »  B-cell receptor-associated protein 31  (Bap31)
 
Protein also known as:  6C6-AG tumor-associated antigen.
Gene name:  BCAP31
Family name: BCAP29/BCAP31
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 39 2
GENE REF ISO

Function

 show evidences
Overview 
Functions as a chaperone protein. Is one of the most abundant endoplasmic reticulum (ER) proteins. Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD). Also serves as a cargo receptor for the export of transmembrane proteins. May be involved in CASP8-mediated apoptosis.  
4
  • UniProtKB
According to TCDB this is a transporter from family:
the general secretory pathway (sec) family  3.A.5.9.1  
GO molecular function 
MHC class I protein bindingdefinition[GO:0042288] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
4
  • IntAct
  • UniProtKB
Protein complex bindingdefinition[GO:0032403] silver  
1
  • Ortholog Compara
GO biological process 
Calcium-mediated signaling using intracellular calcium sourcedefinition[GO:0035584]  
1
  • UniProtKB
ER to Golgi vesicle-mediated transportdefinition[GO:0006888] silver  
1
  • Ortholog Compara
Intracellular protein transportdefinition[GO:0006886] silver  
1
  • InterPro 2 GO
Negative regulation of endoplasmic reticulum calcium ion concentrationdefinition[GO:0032471]  
1
  • UniProtKB
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0043280]  
1
  • UniProtKB
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • UniProtKB
Positive regulation of intrinsic apoptotic signaling pathwaydefinition[GO:2001244]  
1
  • UniProtKB
Positive regulation of mitochondrial calcium ion concentrationdefinition[GO:0051561]  
1
  • UniProtKB
Protein localization to endoplasmic reticulum exit sitedefinition[GO:0070973] silver  
1
  • Ortholog Compara
Spermatogenesisdefinition[GO:0007283] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Protein processing in endoplasmic reticulum  hsa04141+10134  
According to Reactome, this protein belongs to the following pathways:
Antigen Presentation: Folding, assembly and peptide loading of class I MHC  REACT_75795  
Apoptotic cleavage of cellular proteins  REACT_107  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
ER-Golgi transport  definition   [KW-0931]
Protein transport  definition   [KW-0653]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: BCAP31
GenomeRNAi: 10134
PRO: PR:P51572