BRCA2 - Breast cancer type 2 susceptibility protein - human protein (Function)
 
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Protein
Gene
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BRCA2 »  Breast cancer type 2 susceptibility protein
 
Protein also known as:  Fanconi anemia group D1 protein.
Gene name:  BRCA2
Entry whose protein(s) existence is based on evidence at protein level
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1 747 1
GENE REF ISO

Function

 show evidences
Overview 
Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and DSS1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed24896180).  
11
  • UniProtKB
GO molecular function 
Gamma-tubulin bindingdefinition[GO:0043015]  
1
  • UniProtKB
H3 histone acetyltransferase activitydefinition[GO:0010484]  
1
  • UniProtKB
H4 histone acetyltransferase activitydefinition[GO:0010485]  
1
  • UniProtKB
Not  Histone acetyltransferase activitydefinition[GO:0004402]  
1
  • UniProtKB
Protease bindingdefinition[GO:0002020]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
27
  • IntAct
  • UniProtKB
Single-stranded DNA bindingdefinition[GO:0003697]  
1
  • UniProtKB
GO biological process 
Brain developmentdefinition[GO:0007420] silver  
1
  • Ortholog Compara
Cell agingdefinition[GO:0007569] silver  
1
  • Ortholog Compara
Centrosome duplicationdefinition[GO:0051298]  
1
  • UniProtKB
Cytokinesisdefinition[GO:0000910]  
1
  • UniProtKB
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatordefinition[GO:0006978] silver  
1
  • Ortholog Compara
Double-strand break repairdefinition[GO:0006302]  
1
  • UniProtKB
Double-strand break repair via homologous recombinationdefinition[GO:0000724]  
1
  • UniProtKB
Female gonad developmentdefinition[GO:0008585] silver  
1
  • Ortholog Compara
Hemopoiesisdefinition[GO:0030097] silver  
1
  • Ortholog Compara
Histone H3 acetylationdefinition[GO:0043966]  
1
  • UniProtKB
Histone H4 acetylationdefinition[GO:0043967]  
1
  • UniProtKB
Inner cell mass cell proliferationdefinition[GO:0001833] silver  
1
  • Ortholog Compara
Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatordefinition[GO:0042771] silver  
1
  • Ortholog Compara
Male meiosis Idefinition[GO:0007141] silver  
1
  • Ortholog Compara
Negative regulation of mammary gland epithelial cell proliferationdefinition[GO:0033600]  
1
  • UniProtKB
Nucleotide-excision repairdefinition[GO:0006289]  
1
  • UniProtKB
Oocyte maturationdefinition[GO:0001556] silver  
1
  • Ortholog Compara
Positive regulation of mitotic cell cycledefinition[GO:0045931] silver  
1
  • Ortholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • UniProtKB
Regulation of cytokinesisdefinition[GO:0032465] silver  
1
  • Ortholog Compara
Replication fork protectiondefinition[GO:0048478] silver  
1
  • Ortholog Compara
Response to gamma radiationdefinition[GO:0010332] silver  
1
  • Ortholog Compara
Response to UV-Cdefinition[GO:0010225] silver  
1
  • Ortholog Compara
Response to X-raydefinition[GO:0010165] silver  
1
  • Ortholog Compara
Spermatogenesisdefinition[GO:0007283] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Fanconi anemia pathway  hsa03460+675  
Homologous recombination  hsa03440+675  
Pancreatic cancer  hsa05212+675  
Pathways in cancer  hsa05200+675  
According to Reactome, this protein belongs to the following pathways:
Fanconi Anemia pathway  REACT_18410  
Meiotic recombination  REACT_27271  
Presynaptic phase of homologous DNA pairing and strand exchange  REACT_408  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
DNA damage  definition   [KW-0227]
DNA recombination  definition   [KW-0233]
DNA repair  definition   [KW-0234]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: BRCA2
GenomeRNAi: 675
PRO: PR:P51587