CYP2J2 - Cytochrome P450 2J2 - human protein (Function)
 
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CYP2J2 »  Cytochrome P450 2J2   [ EC 1.14.14.1 ]
 
Protein also known as:  Arachidonic acid epoxygenase.
Gene name:  CYP2J2
Family name: Cytochrome P450
Entry whose protein(s) existence is based on evidence at protein level
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1 58 1
GENE REF ISO

Function

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Overview 
This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools.  
  • CuratedUniProtKB
GO molecular function 
Arachidonic acid 11,12-epoxygenase activitydefinition[GO:0008405]  
1
  • IDABHF-UCL
Arachidonic acid 14,15-epoxygenase activitydefinition[GO:0008404]  
1
  • IDABHF-UCL
Arachidonic acid epoxygenase activitydefinition[GO:0008392]  
1
  • IDABHF-UCL
Aromatase activitydefinition[GO:0070330]  
  • IEAEC 2 GO
Heme bindingdefinition[GO:0020037] silver  
  • IEAInterPro 2 GO
Iron ion bindingdefinition[GO:0005506] silver  
  • IEAInterPro 2 GO
Linoleic acid epoxygenase activitydefinition[GO:0071614]  
1
  • IDABHF-UCL
GO biological process 
Epoxygenase P450 pathwaydefinition[GO:0019373]  
1
  • IDABHF-UCL
Icosanoid metabolic processdefinition[GO:0006690]  
1
  • TASPINC
Linoleic acid metabolic processdefinition[GO:0043651]  
1
  • IDABHF-UCL
Oxidation-reduction processdefinition[GO:0055114]  
  • IEAUniProtKB KW
Regulation of heart contractiondefinition[GO:0008016]  
1
  • TASPINC
Xenobiotic metabolic processdefinition[GO:0006805]  
1
  • TASBHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.14.14.1: RH + reduced flavoprotein + O(2) ROH + oxidized flavoprotein + H(2)O.  
  • CuratedUniProtKB
It requires the following cofactor
Heme group (By similarity).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Arachidonic acid metabolism  hsa00590+1573  
Linoleic acid metabolism  hsa00591+1573  
Metabolic pathways  hsa01100+1573  
According to Reactome, this protein belongs to the following pathways:
Fatty acids  REACT_13814  
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)  REACT_150417  
Xenobiotics  REACT_13543  
 

Keywords

Molecular function 
Monooxygenase  definition   [KW-0503]
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CYP2J2
GenomeRNAi: 1573
PRO: PR:P51589