RENBP - N-acylglucosamine 2-epimerase - human protein (Function)
 
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References

 
RENBP »  N-acylglucosamine 2-epimerase   [ EC 5.1.3.8 ]  (AGE)
 
Protein also known as:  N-acetyl-D-glucosamine 2-epimerase.
Gene name:  RENBP
Entry whose protein(s) existence is based on evidence at protein level
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1 16 2
GENE REF ISO

Function

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Overview 
Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded.  
1
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524] silver  
  • IEAOrtholog Compara
Endopeptidase inhibitor activitydefinition[GO:0004866]  
1
  • TASPINC
N-acylglucosamine 2-epimerase activitydefinition[GO:0050121]  
  • ISSOrtholog Curator
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
GO biological process 
N-acetylglucosamine metabolic processdefinition[GO:0006044] silver  
  • IEAOrtholog Compara
N-acetylmannosamine metabolic processdefinition[GO:0006051] silver  
  • IEAOrtholog Compara
N-acetylneuraminate catabolic processdefinition[GO:0019262]  
1
  • TASUniProtKB
  • IEAUniPathway
Regulation of blood pressuredefinition[GO:0008217]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.1.3.8: N-acyl-D-glucosamine N-acyl-D-mannosamine.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathway:
Amino sugar and nucleotide sugar metabolism  hsa00520+5973  
 

Keywords

Molecular function 
Isomerase  definition   [KW-0413]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P51606
Other
GeneWiki: RENBP
GenomeRNAi: 5973
PRO: PR:P51606