MECP2 - Methyl-CpG-binding protein 2 - human protein (Function)
 
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MECP2 »  Methyl-CpG-binding protein 2  (MeCp2)
 
Gene name:  MECP2
Entry whose protein(s) existence is based on evidence at protein level
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1 340 2
GENE REF ISO

Function

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Overview 
Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).  
2
  • UniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682] silver  
1
  • Ortholog Compara
DNA bindingdefinition[GO:0003677]  
1
  • PINC
Double-stranded methylated DNA bindingdefinition[GO:0010385]  
1
  • MGI
Histone deacetylase bindingdefinition[GO:0042826] silver  
1
  • InterPro 2 GO
Methyl-CpG bindingdefinition[GO:0008327]  
1
  • RefGenome
mRNA bindingdefinition[GO:0003729] silver  
1
  • Ortholog Compara
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
Protein domain specific bindingdefinition[GO:0019904]  
1
  • UniProtKB
Protein N-terminus bindingdefinition[GO:0047485]  
1
  • UniProtKB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
1
  • Ortholog Compara
siRNA bindingdefinition[GO:0035197] silver  
1
  • Ortholog Compara
Transcription corepressor activitydefinition[GO:0003714]  
1
  • PINC
Transcription factor bindingdefinition[GO:0008134] silver  
1
  • Ortholog Compara
GO biological process 
Adult locomotory behaviordefinition[GO:0008344] silver  
1
  • Ortholog Compara
Behavioral fear responsedefinition[GO:0001662] silver  
1
  • Ortholog Compara
Cardiolipin metabolic processdefinition[GO:0032048] silver  
1
  • Ortholog Compara
Catecholamine secretiondefinition[GO:0050432] silver  
1
  • Ortholog Compara
Cerebellum developmentdefinition[GO:0021549] silver  
1
  • Ortholog Compara
Chromatin silencingdefinition[GO:0006342] silver  
1
  • Ortholog Compara
Dendrite developmentdefinition[GO:0016358] silver  
1
  • Ortholog Compara
Glucocorticoid metabolic processdefinition[GO:0008211] silver  
1
  • Ortholog Compara
Glutamine metabolic processdefinition[GO:0006541] silver  
1
  • Ortholog Compara
Histone acetylationdefinition[GO:0016573] silver  
1
  • Ortholog Compara
Histone methylationdefinition[GO:0016571] silver  
1
  • Ortholog Compara
Inositol metabolic processdefinition[GO:0006020] silver  
1
  • Ortholog Compara
Locomotory behaviordefinition[GO:0007626]  
1
  • RefGenome
Long-term memorydefinition[GO:0007616] silver  
1
  • Ortholog Compara
Long-term synaptic potentiationdefinition[GO:0060291] silver  
1
  • Ortholog Compara
Mitochondrial electron transport, ubiquinol to cytochrome cdefinition[GO:0006122] silver  
1
  • Ortholog Compara
Negative regulation of histone acetylationdefinition[GO:0035067] silver  
1
  • Ortholog Compara
Negative regulation of histone methylationdefinition[GO:0031061] silver  
1
  • Ortholog Compara
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
1
  • Ortholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
1
  • InterPro 2 GO
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • UniProtKB
Neurological system process involved in regulation of systemic arterial blood pressuredefinition[GO:0001976] silver  
1
  • Ortholog Compara
Neuron maturationdefinition[GO:0042551] silver  
1
  • Ortholog Compara
Pathogenesisdefinition[GO:0009405] silver  
1
  • Ortholog Compara
Phosphatidylcholine metabolic processdefinition[GO:0046470] silver  
1
  • Ortholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
1
  • Ortholog Compara
Positive regulation of synapse assemblydefinition[GO:0051965] silver  
1
  • Ortholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893] silver  
1
  • Ortholog Compara
Post-embryonic developmentdefinition[GO:0009791] silver  
1
  • Ortholog Compara
Proprioceptiondefinition[GO:0019230] silver  
1
  • Ortholog Compara
Protein localizationdefinition[GO:0008104] silver  
1
  • Ortholog Compara
Regulation of excitatory postsynaptic membrane potentialdefinition[GO:0060079] silver  
1
  • Ortholog Compara
Regulation of gene expression by genetic imprintingdefinition[GO:0006349] silver  
1
  • Ortholog Compara
Regulation of respiratory gaseous exchange by neurological system processdefinition[GO:0002087] silver  
1
  • Ortholog Compara
Respiratory gaseous exchangedefinition[GO:0007585] silver  
1
  • Ortholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
1
  • Ortholog Compara
Response to radiationdefinition[GO:0009314]  
1
  • RefGenome
Sensory perception of paindefinition[GO:0019233] silver  
1
  • Ortholog Compara
Social behaviordefinition[GO:0035176] silver  
1
  • Ortholog Compara
Startle responsedefinition[GO:0001964] silver  
1
  • Ortholog Compara
Synapse assemblydefinition[GO:0007416] silver  
1
  • Ortholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
Ventricular system developmentdefinition[GO:0021591] silver  
1
  • Ortholog Compara
Visual learningdefinition[GO:0008542] silver  
1
  • Ortholog Compara
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MECP2
GenomeRNAi: 4204
PRO: PR:P51608