ALDH3A2 - Fatty aldehyde dehydrogenase - human protein (Function)
 
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Protein
Gene
References

 
ALDH3A2 »  Fatty aldehyde dehydrogenase   [ EC 1.2.1.3 ]
 
Protein also known as:  Aldehyde dehydrogenase family 3 member A2.
Gene name:  ALDH3A2
Family name: Aldehyde dehydrogenase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 41 2
GENE REF ISO

Function

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Overview 
Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid.  
1
  • CuratedUniProtKB
GO molecular function 
Aldehyde dehydrogenase (NAD) activitydefinition[GO:0004029]  
3
  • IMPUniProtKB
Aldehyde dehydrogenase [NAD(P)+] activitydefinition[GO:0004030] silver  
  • IEAInterPro 2 GO
Long-chain-alcohol oxidase activitydefinition[GO:0046577]  
1
  • IDAUniProtKB
Isoform  Iso 1   Long-chain-aldehyde dehydrogenase activitydefinition[GO:0050061]  
1
  • IDAUniProtKB
Isoform  Iso 1   Medium-chain-aldehyde dehydrogenase activitydefinition[GO:0052814]  
1
  • IDAUniProtKB
GO biological process 
Cellular aldehyde metabolic processdefinition[GO:0006081]  
2
  • IDAUniProtKB
Central nervous system developmentdefinition[GO:0007417]  
1
  • IMPUniProtKB
Epidermis developmentdefinition[GO:0008544]  
1
  • IMPUniProtKB
Oxidation-reduction processdefinition[GO:0055114]  
2
  • IDAGOC
  • IDAUniProtKB
Peripheral nervous system developmentdefinition[GO:0007422]  
1
  • IMPUniProtKB
Phytol metabolic processdefinition[GO:0033306]  
1
  • IMPUniProtKB
Isoform  Iso 1   Sesquiterpenoid metabolic processdefinition[GO:0006714]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.2.1.3: An aldehyde + NAD(+) + H(2)O a carboxylate + NADH.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Arginine and proline metabolism  hsa00330+224  
Ascorbate and aldarate metabolism  hsa00053+224  
beta-Alanine metabolism  hsa00410+224  
Fatty acid metabolism  hsa00071+224  
Glycerolipid metabolism  hsa00561+224  
Glycolysis / Gluconeogenesis  hsa00010+224  
Histidine metabolism  hsa00340+224  
Lysine degradation  hsa00310+224  
Metabolic pathways  hsa01100+224  
Pentose and glucuronate interconversions  hsa00040+224  
Propanoate metabolism  hsa00640+224  
Pyruvate metabolism  hsa00620+224  
Tryptophan metabolism  hsa00380+224  
Valine, leucine and isoleucine degradation  hsa00280+224  
 
More information is available from:
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P51648
Other
GenomeRNAi: 224
PRO: PR:P51648