ALDH5A1 - Succinate-semialdehyde dehydrogenase, mitochondrial - human protein (Function)
 
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ALDH5A1 »  Succinate-semialdehyde dehydrogenase, mitochondrial   [ EC 1.2.1.24 ]
 
Protein also known as:  NAD(+)-dependent succinic semialdehyde dehydrogenase.
Gene name:  ALDH5A1
Family name: Aldehyde dehydrogenase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

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Overview 
Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).  
1
  • CuratedUniProtKB
GO molecular function 
Protein homodimerization activitydefinition[GO:0042803]  
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  • ICUniProtKB
Succinate-semialdehyde dehydrogenase (NAD+) activitydefinition[GO:0004777]  
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  • IDAUniProtKB
Succinate-semialdehyde dehydrogenase [NAD(P)+] activitydefinition[GO:0009013] silver  
  • IEAInterPro 2 GO
GO biological process 
Acetate metabolic processdefinition[GO:0006083]  
  • ISSOrtholog Curator
Central nervous system developmentdefinition[GO:0007417]  
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  • IMPUniProtKB
Galactosylceramide metabolic processdefinition[GO:0006681]  
  • ISSOrtholog Curator
Gamma-aminobutyric acid catabolic processdefinition[GO:0009450]  
2
  • IMPUniProtKB
  • IEAUniPathway
Glucose metabolic processdefinition[GO:0006006]  
  • ISSOrtholog Curator
Glucosylceramide metabolic processdefinition[GO:0006678] silver  
  • IEAOrtholog Compara
Glutamate metabolic processdefinition[GO:0006536]  
  • ISSOrtholog Curator
Glutamine metabolic processdefinition[GO:0006541]  
  • ISSOrtholog Curator
Glutathione metabolic processdefinition[GO:0006749]  
  • ISSOrtholog Curator
Glycerophospholipid metabolic processdefinition[GO:0006650]  
  • ISSOrtholog Curator
Neurotransmitter catabolic processdefinition[GO:0042135]  
  • ISSOrtholog Curator
Post-embryonic developmentdefinition[GO:0009791] silver  
  • IEAOrtholog Compara
Protein homotetramerizationdefinition[GO:0051289]  
1
  • IDAUniProtKB
Respiratory electron transport chaindefinition[GO:0022904]  
  • ISSOrtholog Curator
Short-chain fatty acid metabolic processdefinition[GO:0046459]  
  • ISSOrtholog Curator
Succinate metabolic processdefinition[GO:0006105]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.2.1.24: Succinate semialdehyde + NAD(+) + H(2)O succinate + NADH.  
  • CuratedUniProtKB
It is regulated in the following manner
Redox-regulated. Inhibited under oxydizing conditions. Inhibited by hydrogen peroxide H(2)O(2).  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Alanine, aspartate and glutamate metabolism  hsa00250+7915  
Butanoate metabolism  hsa00650+7915  
Metabolic pathways  hsa01100+7915  
According to Reactome, this protein belongs to the following pathway:
Neuronal System  REACT_13685  
 
More information is available from:
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P51649
Other
GeneWiki: Aldehyde_dehydrogenase_5_family,_member_A1
GenomeRNAi: 7915
PRO: PR:P51649