GPC3 - Glypican-3 - human protein (Function)
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GPC3 »  Glypican-3
Protein also known as:  Intestinal protein OCI-5. Cleaved into:  Secreted glypican-3.
Gene name:  GPC3
Family name: Glypican
Entry whose protein(s) existence is based on evidence at protein level
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Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition.  
  • CuratedUniProtKB
GO molecular function 
Heparan sulfate proteoglycan bindingdefinition[GO:0043395] silver  
  • IEAInterPro 2 GO
Peptidyl-dipeptidase inhibitor activitydefinition[GO:0060422]  
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
  • IPIUniProtKB
GO biological process 
Anatomical structure morphogenesisdefinition[GO:0009653]  
Anterior/posterior axis specificationdefinition[GO:0009948] silver  
  • IEAOrtholog Compara
Body morphogenesisdefinition[GO:0010171] silver  
  • IEAOrtholog Compara
Bone mineralizationdefinition[GO:0030282] silver  
  • IEAOrtholog Compara
Branching involved in ureteric bud morphogenesisdefinition[GO:0001658] silver  
  • IEAOrtholog Compara
Cell proliferation involved in metanephros developmentdefinition[GO:0072203] silver  
  • IEAOrtholog Compara
Coronary vasculature developmentdefinition[GO:0060976] silver  
  • IEAOrtholog Compara
Embryonic hindlimb morphogenesisdefinition[GO:0035116] silver  
  • IEAOrtholog Compara
Lung developmentdefinition[GO:0030324] silver  
  • IEAOrtholog Compara
Mesenchymal cell proliferation involved in ureteric bud developmentdefinition[GO:0072138]  
  • ISSOrtholog Curator
Mesonephric duct morphogenesisdefinition[GO:0072180] silver  
  • IEAOrtholog Compara
Negative regulation of canonical Wnt signaling pathwaydefinition[GO:0090090] silver  
  • IEAOrtholog Compara
Negative regulation of epithelial cell proliferationdefinition[GO:0050680] silver  
  • IEAOrtholog Compara
Negative regulation of growthdefinition[GO:0045926] silver  
  • IEAOrtholog Compara
Negative regulation of peptidase activitydefinition[GO:0010466]  
  • IEAUniProtKB KW
Negative regulation of smoothened signaling pathwaydefinition[GO:0045879] silver  
  • IEAOrtholog Compara
Osteoclast differentiationdefinition[GO:0030316] silver  
  • IEAOrtholog Compara
Positive regulation of BMP signaling pathwaydefinition[GO:0030513] silver  
  • IEAOrtholog Compara
Positive regulation of endocytosisdefinition[GO:0045807] silver  
  • IEAOrtholog Compara
Positive regulation of glucose importdefinition[GO:0046326] silver  
  • IEAOrtholog Compara
Positive regulation of protein catabolic processdefinition[GO:0045732] silver  
  • IEAOrtholog Compara
Positive regulation of smoothened signaling pathwaydefinition[GO:0045880] silver  
  • IEAOrtholog Compara
Positive regulation of Wnt signaling pathway, planar cell polarity pathwaydefinition[GO:2000096] silver  
  • IEAOrtholog Compara
According to Reactome, this protein belongs to the following pathways:
A tetrasaccharide linker sequence is required for GAG synthesis  REACT_121408  
HS-GAG biosynthesis  REACT_121248  
HS-GAG degradation  REACT_120752  
Retinoid metabolism and transport  REACT_24968  


Molecular function 
Protease inhibitor  definition   [KW-0646]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: Glypican_3
GenomeRNAi: 2719
PRO: PR:P51654