HSD17B4 - Peroxisomal multifunctional enzyme type 2 - human protein (Function)
 
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Protein
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References

 
HSD17B4 »  Peroxisomal multifunctional enzyme type 2  (MFE-2)
 
Protein also known as:  17-beta-hydroxysteroid dehydrogenase 4 (17-beta-HSD 4). Cleaved into:  (3R)-hydroxyacyl-CoA dehydrogenase; Enoyl-CoA hydratase 2.
Gene name:  HSD17B4
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

 show evidences
Overview 
Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids.  
2
  • CuratedUniProtKB
GO molecular function 
17-beta-hydroxysteroid dehydrogenase (NAD+) activitydefinition[GO:0044594]  
1
  • IDAUniProtKB
3-hydroxyacyl-CoA dehydrogenase activitydefinition[GO:0003857]  
2
  • IMPUniProtKB
Isomerase activitydefinition[GO:0016853]  
  • IEAUniProtKB KW
Long-chain-enoyl-CoA hydratase activitydefinition[GO:0016508]  
3
  • IDAUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
2
  • IDAUniProtKB
Receptor bindingdefinition[GO:0005102]  
1
  • IPIUniProtKB
Sterol bindingdefinition[GO:0032934] silver  
  • IEAInterPro 2 GO
GO biological process 
Androgen metabolic processdefinition[GO:0008209]  
1
  • IDAUniProtKB
Estrogen metabolic processdefinition[GO:0008210]  
1
  • IDAUniProtKB
Fatty acid beta-oxidationdefinition[GO:0006635]  
1
  • IDAUniProtKB
Medium-chain fatty-acyl-CoA metabolic processdefinition[GO:0036112]  
1
  • IDAUniProtKB
Metabolic processdefinition[GO:0008152]  
1
  • IDAGOC
Oxidation-reduction processdefinition[GO:0055114]  
2
  • IMPGOC
Sertoli cell developmentdefinition[GO:0060009] silver  
  • IEAOrtholog Compara
Very long-chain fatty acid metabolic processdefinition[GO:0000038] silver  
  • IEAOrtholog Compara
Very long-chain fatty-acyl-CoA metabolic processdefinition[GO:0036111]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 1.1.1.-: (R)-3-hydroxyacyl-CoA + NAD(+) 3-oxoacyl-CoA + NADH.  
1
  • CuratedUniProtKB
EC 4.2.1.107: (24R,25R)-3-alpha,7-alpha,12-alpha,24-tetrahydroxy-5-beta-cholestanoyl-CoA (24E)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA + H(2)O.  
1
  • CuratedUniProtKB
EC 4.2.1.119: (3R)-3-hydroxyacyl-CoA (2E)-2-enoyl-CoA + H(2)O.  
1
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+3295  
Peroxisome  hsa04146+3295  
Primary bile acid biosynthesis  hsa00120+3295  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
Note 
The protein is found both as a full length peptide and in a cleaved version.  
  • CuratedUniProtKB
 

Biophysicochemical properties

Kinetic parameters
KM 2.7 uM for 3-ketooctanoyl-CoA
KM 5.4 uM for NADH
KM 10 uM for D-3-hydroxy-octanoyl-CoA
KM 13 uM for NAD
Vmax 8.8 umol/min/mg enzyme

Keywords

Biological process 
Fatty acid metabolism  definition   [KW-0276]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Isomerase  definition   [KW-0413]
Lyase  definition   [KW-0456]
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P51659
Other
GeneWiki: HSD17B4
GenomeRNAi: 3295
PRO: PR:P51659