UBE2D1 - Ubiquitin-conjugating enzyme E2 D1 - human protein (Function)
 
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UBE2D1 »  Ubiquitin-conjugating enzyme E2 D1   [ EC 2.3.2.23 ]
 
Protein also known as:  (E3-independent) E2 ubiquitin-conjugating enzyme D1 [EC 2.3.2.24].
Gene name:  UBE2D1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4.  
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GO molecular function 
ATP bindingdefinition[GO:0005524]  
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  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
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  • IntAct
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Ubiquitin conjugating enzyme activitydefinition[GO:0061631]  
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  • MGI
  • BHF-UCL
Ubiquitin-protein transferase activitydefinition[GO:0004842]  
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  • UniProtKB
GO biological process 
Positive regulation of protein ubiquitinationdefinition[GO:0031398]  
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Protein K48-linked ubiquitinationdefinition[GO:0070936]  
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  • UniProtKB
Protein polyubiquitinationdefinition[GO:0000209]  
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  • UniProtKB
  • BHF-UCL
Ubiquitin-dependent protein catabolic processdefinition[GO:0006511]  
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  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 2.3.2.23: S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.  
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  • UniProtKB
  • PROSITE-ProRule
EC 2.3.2.24: S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.  
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  • UniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
Protein modification; protein ubiquitination  
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  • UniProtKB
  • PROSITE-ProRule
According to KEGG, this protein belongs to the following pathways:
Protein processing in endoplasmic reticulum  hsa04141+7321  
Ubiquitin mediated proteolysis  hsa04120+7321  
According to Reactome, this protein belongs to the following pathways:
Antigen processing: Ubiquitination & Proteasome degradation  R-HSA-983168  
APC-Cdc20 mediated degradation of Nek2A  R-HSA-179409  
APC/C:Cdc20 mediated degradation of Cyclin B  R-HSA-174048  
APC/C:Cdc20 mediated degradation of mitotic proteins  R-HSA-176409  
APC/C:Cdc20 mediated degradation of Securin  R-HSA-174154  
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1  R-HSA-174178  
Autodegradation of Cdh1 by Cdh1:APC/C  R-HSA-174084  
Cdc20:Phospho-APC/C mediated degradation of Cyclin A  R-HSA-174184  
CLEC7A (Dectin-1) signaling  R-HSA-5607764  
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase  R-HSA-176407  
Downregulation of SMAD2/3:SMAD4 transcriptional activity  R-HSA-2173795  
Downstream TCR signaling  R-HSA-202424  
FCERI mediated NF-kB activation  R-HSA-2871837  
IKK complex recruitment mediated by RIP1  R-HSA-937041  
Inactivation of APC/C via direct inhibition of the APC/C complex  R-HSA-141430  
Negative regulators of RIG-I/MDA5 signaling  R-HSA-936440  
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha  R-HSA-1234176  
Phosphorylation of the APC/C  R-HSA-176412  
Regulation of APC/C activators between G1/S and early anaphase  R-HSA-176408  
Senescence-Associated Secretory Phenotype (SASP)  R-HSA-2559582  
Separation of Sister Chromatids  R-HSA-2467813  
Signaling by BMP  R-HSA-201451  
Caution 
PubMed:9362508 cloned and sequenced SFT which consisted of UBE2D1 last coding exon along with intronic sequences on the 5'-end of this exon. A function in iron transport has been described.  
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Keywords

Biological process 
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: UBE2D1
GenomeRNAi: 7321
PRO: PR:P51668