UBE2D1 - Ubiquitin-conjugating enzyme E2 D1 - human protein (Function)
 
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UBE2D1 »  Ubiquitin-conjugating enzyme E2 D1   [ EC 6.3.2.19 ]
 
Protein also known as:  Ubiquitin-conjugating enzyme E2-17 kDa 1.
Gene name:  UBE2D1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

 show evidences
Overview 
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4.  
5
  • CuratedUniProtKB
GO molecular function 
Acid-amino acid ligase activitydefinition[GO:0016881] silver  
  • IEAInterPro 2 GO
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
7
  • IPIIntAct
  • IPIUniProtKB
Ubiquitin-protein transferase activitydefinition[GO:0004842]  
4
  • IDAMGI
  • IDAUniProtKB
  • IDABHF-UCL
GO biological process 
Positive regulation of protein ubiquitinationdefinition[GO:0031398]  
1
  • IDAUniProtKB
Protein K48-linked ubiquitinationdefinition[GO:0070936]  
1
  • IDAUniProtKB
Protein polyubiquitinationdefinition[GO:0000209]  
2
  • IDAUniProtKB
  • IDABHF-UCL
Ubiquitin-dependent protein catabolic processdefinition[GO:0006511]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.3.2.19: ATP + ubiquitin + protein lysine AMP + diphosphate + protein N-ubiquityllysine.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Protein processing in endoplasmic reticulum  hsa04141+7321  
Ubiquitin mediated proteolysis  hsa04120+7321  
According to Reactome, this protein belongs to the following pathways:
Antigen processing: Ubiquitination & Proteasome degradation  REACT_75842  
APC/C:Cdc20 mediated degradation of Cyclin B  REACT_6820  
APC/C:Cdc20 mediated degradation of mitotic proteins  REACT_6781  
APC/C:Cdc20 mediated degradation of Securin  REACT_6871  
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1  REACT_6761  
Autodegradation of Cdh1 by Cdh1:APC/C  REACT_6785  
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase  REACT_6867  
Downregulation of SMAD2/3:SMAD4 transcriptional activity  REACT_121111  
IKK complex recruitment mediated by RIP1  REACT_25374  
Inactivation of APC/C via direct inhibition of the APC/C complex  REACT_1072  
Negative regulators of RIG-I/MDA5 signaling  REACT_25271  
Negative regulators of RIG-I/MDA5 signaling  REACT_198532  
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha  REACT_120916  
Phosphorylation of the APC/C  REACT_6904  
Regulation of APC/C activators between G1/S and early anaphase  REACT_6837  
Senescence-Associated Secretory Phenotype (SASP)  REACT_169168  
Separation of Sister Chromatids  REACT_150471  
Signaling by BMP  REACT_12034  
Caution 
PubMed9362508 cloned and sequenced SFT which consisted of UBE2D1 last coding exon along with intronic sequences on the 5'-end of this exon. A function in iron transport has been described.  
1
  • CuratedUniProtKB
 

Keywords

Biological process 
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: UBE2D1
GenomeRNAi: 7321
PRO: PR:P51668