GPM6A - Neuronal membrane glycoprotein M6-a - human protein (Function)
 
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GPM6A »  Neuronal membrane glycoprotein M6-a  (M6a)
 
Gene name:  GPM6A
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor.  
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  • CuratedUniProtKB
GO molecular function 
Calcium channel activitydefinition[GO:0005262] silver  
  • IEAOrtholog Compara
GO biological process 
Neural retina developmentdefinition[GO:0003407]  
  • ISSOrtholog Curator
Neuron migrationdefinition[GO:0001764]  
1
  • IDAUniProtKB
Neuron projection morphogenesisdefinition[GO:0048812]  
  • ISSOrtholog Curator
Positive regulation of filopodium assemblydefinition[GO:0051491]  
  • ISSOrtholog Curator
Stem cell differentiationdefinition[GO:0048863]  
1
  • IDAUniProtKB
Synapse assemblydefinition[GO:0007416]  
  • ISSOrtholog Curator
 

Keywords

Biological process 
Neurogenesis  definition   [KW-0524]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GPM6A
GenomeRNAi: 2823
PRO: PR:P51674