CCR3 - C-C chemokine receptor type 3 - human protein (Function)
 
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CCR3 »  C-C chemokine receptor type 3  (CCR3)
 
Protein also known as:  Eosinophil eotaxin receptor; CD antigen CD193.
Gene name:  CCR3
Entry whose protein(s) existence is based on evidence at protein level
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1 83 2
GENE REF ISO

Function

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Overview 
Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.  
  • CuratedUniProtKB
GO molecular function 
C-C chemokine receptor activitydefinition[GO:0016493] silver  
  • IEAOrtholog Compara
Chemokine receptor activitydefinition[GO:0004950]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
Adenylate cyclase-modulating G-protein coupled receptor signaling pathwaydefinition[GO:0007188]  
1
  • TASPINC
Cell adhesiondefinition[GO:0007155]  
1
  • TASPINC
Cellular defense responsedefinition[GO:0006968]  
1
  • TASPINC
Chemokine-mediated signaling pathwaydefinition[GO:0070098]  
1
  • TASGOC
  • IEAInterPro 2 GO
  • IEAOrtholog Compara
Chemotaxisdefinition[GO:0006935] silver  
  • IEAOrtholog Compara
Inflammatory responsedefinition[GO:0006954] silver  
  • IEAInterPro 2 GO
Positive regulation of angiogenesisdefinition[GO:0045766]  
1
  • IMPBHF-UCL
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • TASPINC
Positive regulation of endothelial cell proliferationdefinition[GO:0001938] silver  
  • IEAOrtholog Compara
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+1232  
Cytokine-cytokine receptor interaction  hsa04060+1232  
According to Reactome, this protein belongs to the following pathways:
Chemokine receptors bind chemokines  REACT_15344  
G alpha (i) signalling events  REACT_19231  
Note 
Overexpression of CCR3 together with its ligands appears to be a characteristic of ulcerative colitis (UC). The production of CCR3 ligands by human colonic epithelial cells suggests further that the epithelium can play a role in modulating pathological T-cell-mediated mucosal inflammation (PubMed21077277).  
1
  • CuratedUniProtKB
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 1232
PRO: PR:P51677
Chemistry
GuidetoPHARMACOLOGY: 60