CCR4 - C-C chemokine receptor type 4 - human protein (Function)
 
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Protein
Gene
References

 
CCR4 »  C-C chemokine receptor type 4  (CCR4)
 
Protein also known as:  K5-5; CD antigen CD194.
Gene name:  CCR4
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.  
6
  • UniProtKB
GO molecular function 
C-C chemokine receptor activitydefinition[GO:0016493] silver  
1
  • Ortholog Compara
Chemokine receptor activitydefinition[GO:0004950]  
1
  • PINC
GO biological process 
Chemokine-mediated signaling pathwaydefinition[GO:0070098]  
3
  • GOC
  • Ortholog Compara
  • InterPro 2 GO
Chemotaxisdefinition[GO:0006935] silver  
1
  • Ortholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • UniProtKB KW
Immune responsedefinition[GO:0006955] silver  
1
  • InterPro 2 GO
Inflammatory responsedefinition[GO:0006954] silver  
1
  • Ortholog Compara
Neuron migrationdefinition[GO:0001764] silver  
1
  • Ortholog Compara
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • PINC
Positive regulation of positive chemotaxisdefinition[GO:0050927] silver  
1
  • Ortholog Compara
Response to antibioticdefinition[GO:0046677] silver  
1
  • Ortholog Compara
Response to bacteriumdefinition[GO:0009617] silver  
1
  • Ortholog Compara
Response to radiationdefinition[GO:0009314] silver  
1
  • Ortholog Compara
Tolerance inductiondefinition[GO:0002507] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+1233  
Cytokine-cytokine receptor interaction  hsa04060+1233  
According to Reactome, this protein belongs to the following pathways:
Chemokine receptors bind chemokines  REACT_15344  
G alpha (i) signalling events  REACT_19231  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CCR4
GenomeRNAi: 1233
PRO: PR:P51679
Chemistry
GuidetoPHARMACOLOGY: 61