CCR5 - C-C chemokine receptor type 5 - human protein (Function)
 
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CCR5 »  C-C chemokine receptor type 5  (CCR5)
 
Protein also known as:  HIV-1 fusion coreceptor; CD antigen CD195.
Gene name:  CCR5
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.  
6
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
1
  • IDAUniProtKB
C-C chemokine bindingdefinition[GO:0019957]  
2
  • IPIUniProtKB
C-C chemokine receptor activitydefinition[GO:0016493]  
2
  • IDAMGI
  • NASUniProtKB
Chemokine (C-C motif) ligand 5 bindingdefinition[GO:0071791]  
1
  • IPIUniProtKB
Chemokine receptor activitydefinition[GO:0004950]  
1
  • TASPINC
Coreceptor activitydefinition[GO:0015026]  
1
  • TASPINC
Phosphatidylinositol phospholipase C activitydefinition[GO:0004435]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
  • IPIUniProtKB
GO biological process 
Calcium ion transportdefinition[GO:0006816]  
1
  • IDAUniProtKB
Calcium-mediated signalingdefinition[GO:0019722]  
2
  • IDAUniProtKB
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • TASPINC
Cell-cell signalingdefinition[GO:0007267]  
1
  • IDAUniProtKB
Cellular defense responsedefinition[GO:0006968]  
1
  • TASPINC
Cellular response to lipopolysaccharidedefinition[GO:0071222]  
1
  • IEPUniProtKB
Chemokine-mediated signaling pathwaydefinition[GO:0070098]  
3
  • IDAGOC
  • IEAInterPro 2 GO
Chemotaxisdefinition[GO:0006935]  
1
  • TASPINC
Dendritic cell chemotaxisdefinition[GO:0002407]  
1
  • TASBHF-UCL
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • IMPUniProtKB
Immune responsedefinition[GO:0006955] silver  
  • IEAInterPro 2 GO
Inflammatory responsedefinition[GO:0006954] silver  
  • IEAInterPro 2 GO
MAPK cascadedefinition[GO:0000165]  
1
  • IEPUniProtKB
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • TASPINC
Release of sequestered calcium ion into cytosol by sarcoplasmic reticulumdefinition[GO:0014808]  
1
  • IDAUniProtKB
Response to cholesteroldefinition[GO:0070723]  
1
  • IMPUniProtKB
Signalingdefinition[GO:0023052]  
1
  • IEPUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+1234  
Cytokine-cytokine receptor interaction  hsa04060+1234  
Endocytosis  hsa04144+1234  
Toxoplasmosis  hsa05145+1234  
According to Reactome, this protein belongs to the following pathways:
Binding and entry of HIV virion  REACT_6903  
Chemokine receptors bind chemokines  REACT_15344  
G alpha (i) signalling events  REACT_19231  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CCR5
GenomeRNAi: 1234
PRO: PR:P51681
Chemistry
GuidetoPHARMACOLOGY: 62