CCR5 - C-C chemokine receptor type 5 - human protein (Sequence)
 
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CCR5 »  C-C chemokine receptor type 5  (CCR5)
 
Protein also known as:  HIV-1 fusion coreceptor; CD antigen CD195.
Gene name:  CCR5
Entry whose protein(s) existence is based on evidence at protein level
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1 446 1
GENE REF ISO

Displayed isoform: Iso 1

 
 
Isoform Iso 1   352 aaMass: 40524 Da,  pI: 9.21
MDYQVSSPIY DINYYTSEPC QKINVKQIAA RLLPPLYSLV FIFGFVGNML VILILINCKR LKSMTDIYLL NLAISDLFFL LTVPFWAHYA AAQWDFGNTM CQLLTGLYFI GFFSGIFFII LLTIDRYLAV VHAVFALKAR TVTFGVVTSV ITWVVAVFAS LPGIIFTRSQ KEGLHYTCSS HFPYSQYQFW KNFQTLKIVI LGLVLPLLVM VICYSGILKT LLRCRNEKKR HRAVRLIFTI MIVYFLFWAP YNIVLLLNTF QEFFGLNNCS SSNRLDQAMQ VTETLGMTHC CINPIIYAFV GEKFRNYLLV FFQKHIAKRF CKCCSIFQQE APERASSVYT RSTGEQEISV GL

Sequence

 show evidences
PTM 
Sulfated on at least 2 of the N-terminal tyrosines. Sulfation contributes to the efficiency of HIV-1 entry and is required for efficient binding of the chemokines, CCL3 and CCL4.  
  • CuratedUniProtKB
O-glycosylated, but not N-glycosylated. Ser-6 appears to be the major site. Also sialylated glycans present which contribute to chemokine binding. Thr-16 and Ser-17 may also be glycosylated and, if so, with small moieties such as a T-antigen.  
2
  • CuratedUniProtKB
Palmitoylation in the C-terminal is important for cell surface expression, and to a lesser extent, for HIV entry.  
1
  • CuratedUniProtKB
Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES.  
  • CuratedUniProtKB
 

Keywords

Coding sequence diversity 
Polymorphism  definition   [KW-0621]
Domain 
Transmembrane  definition   [KW-0812]
Transmembrane helix  definition   [KW-1133]
PTM 
Disulfide bond  definition   [KW-1015]
Glycoprotein  definition   [KW-0325]
Lipoprotein  definition   [KW-0449]
Palmitate  definition   [KW-0564]
Phosphoprotein  definition   [KW-0597]
Sulfation  definition   [KW-0765]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Family and domain databases
Gene3D: 1.20.1070.10
InterPro: IPR002237 [ Chemokine CCR2 ]
InterPro: IPR000355 [ Chemokine rcpt ]
InterPro: IPR000276 [ GPCR Rhodpsn ]
InterPro: IPR017452 [ GPCR Rhodpsn 7TM ]
InterPro: IPR002240 [ Chemokine CCR5 ]
PANTHER: PTHR24227 [ PTHR24227 ]
Pfam: PF00001 [ 7tm 1 ]
PRINTS: PR00657 [ CCCHEMOKINER ]
PRINTS: PR01110 [ CHEMOKINER5 ]
PRINTS: PR00237 [ GPCRRHODOPSN ]
PROSITE: PS50262 [ G PROTEIN RECEP F1 2 ]
PROSITE: PS00237 [ G PROTEIN RECEP F1 1 ]
Genome annotation databases
Ensembl: Transcript: ENST00000292303;  Protein: ENSP00000292303;  Gene: ENSG00000160791.
Ensembl: Transcript: ENST00000343801;  Protein: ENSP00000343985;  Gene: ENSG00000160791.
Ensembl: Transcript: ENST00000445772;  Protein: ENSP00000404881;  Gene: ENSG00000160791.
KEGG: hsa:1234
UCSC: uc003cpo.4
Organism-specific databases
MGI: MGI:107182 [ Ccr5 ]
Other
EvolutionaryTrace: P51681
PTM databases
PhosphoSite: P51681
Phylogenomic databases
eggNOG: NOG148353
HOVERGEN: HBG106917
InParanoid: P51681
KO: K04180
OMA: IIFTRSQ
OrthoDB: EOG738051
PhylomeDB: P51681
Sequence databases
CCDS: CCDS2739.1 [ P51681-1 ]
EMBL: mRNA:  AF011505 . Translation:  AAB65705.1 .
EMBL: mRNA:  AF011530 . Translation:  AAB65730.1 .
EMBL: mRNA:  U54994 . Translation:  AAC50598.1 .
EMBL: mRNA:  AF011502 . Translation:  AAB65702.1 .
EMBL: mRNA:  AF011501 . Translation:  AAB65701.1 .
EMBL: mRNA:  AF011510 . Translation:  AAB65710.1 .
EMBL: mRNA:  AF011528 . Translation:  AAB65728.1 .
EMBL: mRNA:  AF011516 . Translation:  AAB65716.1 .
EMBL: mRNA:  AF011536 . Translation:  AAB65736.1 .
EMBL: mRNA:  AF011513 . Translation:  AAB65713.1 .
EMBL: mRNA:  AF011506 . Translation:  AAB65706.1 .
EMBL: mRNA:  AF011512 . Translation:  AAB65712.1 .
EMBL: mRNA:  AF011511 . Translation:  AAB65711.1 .
EMBL: mRNA:  AF011535 . Translation:  AAB65735.1 .
EMBL: Genomic DNA:  U95626 . Translation:  AAB57793.1 .
EMBL: mRNA:  AF011525 . Translation:  AAB65725.1 .
EMBL: mRNA:  AF011520 . Translation:  AAB65720.1 .
EMBL: mRNA:  AF011533 . Translation:  AAB65733.1 .
EMBL: Genomic DNA:  AY221093 . Translation:  AAO65971.1 .
EMBL: mRNA:  AF011507 . Translation:  AAB65707.1 .
EMBL: mRNA:  U57840 . Translation:  AAB17071.1 .
EMBL: mRNA:  AF011514 . Translation:  AAB65714.1 .
EMBL: mRNA:  AF011518 . Translation:  AAB65718.1 .
EMBL: mRNA:  AF011519 . Translation:  AAB65719.1 .
EMBL: mRNA:  BC038398 . Translation:  AAH38398.1 .
EMBL: mRNA:  AF011521 . Translation:  AAB65721.1 .
EMBL: mRNA:  AF011522 . Translation:  AAB65722.1 .
EMBL: mRNA:  AF011515 . Translation:  AAB65715.1 .
EMBL: mRNA:  AF011537 . Translation:  AAB65737.1 .
EMBL: Genomic DNA:  AF031237 . Translation:  AAB94735.1 .
EMBL: mRNA:  AF011523 . Translation:  AAB65723.1 .
EMBL: Genomic DNA:  U83326 . Translation:  AAC51797.1 .
EMBL: mRNA:  AF011526 . Translation:  AAB65726.1 .
EMBL: mRNA:  AF011534 . Translation:  AAB65734.1 .
EMBL: mRNA:  AF011503 . Translation:  AAB65703.1 .
EMBL: mRNA:  AF011532 . Translation:  AAB65732.1 .
EMBL: mRNA:  AF011509 . Translation:  AAB65709.1 .
EMBL: mRNA:  AF011500 . Translation:  AAB65700.1 .
EMBL: mRNA:  AF011517 . Translation:  AAB65717.1 .
EMBL: mRNA:  AF011529 . Translation:  AAB65729.1 .
EMBL: mRNA:  AF011527 . Translation:  AAB65727.1 .
EMBL: mRNA:  AF011524 . Translation:  AAB65724.1 .
EMBL: mRNA:  AF011508 . Translation:  AAB65708.1 .
EMBL: Genomic DNA:  X91492 . Translation:  CAA62796.1 .
EMBL: mRNA:  AF011531 . Translation:  AAB65731.1 .
EMBL: Genomic DNA:  AF052539 . Translation:  AAD18131.1 .
IPI: IPI00743929
PIR: A43113
RefSeq: Protein:  NP_000570.1. Nucleotide sequence:  NM_000579.3.
RefSeq: Protein:  NP_001093638.1. Nucleotide sequence:  NM_001100168.1.
UniProtKB: P51681 [ CCR5 ]