CCR6 - C-C chemokine receptor type 6 - human protein (Function)
 
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CCR6 »  C-C chemokine receptor type 6  (CCR-6)
 
Protein also known as:  G-protein coupled receptor 29; CD antigen CD196.
Gene name:  CCR6
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Receptor for a C-C type chemokine. Binds to MIP-3-alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level.  
1
  • CuratedUniProtKB
GO molecular function 
C-C chemokine receptor activitydefinition[GO:0016493] silver  
  • IEAInterPro 2 GO
Chemokine receptor activitydefinition[GO:0004950]  
1
  • TASPINC
Receptor activitydefinition[GO:0004872]  
1
  • TASPINC
GO biological process 
Cellular component movementdefinition[GO:0006928]  
1
  • TASPINC
Cellular defense responsedefinition[GO:0006968]  
1
  • TASPINC
Chemokine-mediated signaling pathwaydefinition[GO:0070098]  
1
  • TASGOC
  • IEAInterPro 2 GO
Chemotaxisdefinition[GO:0006935]  
1
  • TASPINC
Dendritic cell chemotaxisdefinition[GO:0002407]  
1
  • TASBHF-UCL
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
  • IEAUniProtKB KW
Humoral immune responsedefinition[GO:0006959]  
1
  • TASPINC
Immune responsedefinition[GO:0006955]  
1
  • TASPINC
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • TASPINC
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+1235  
Cytokine-cytokine receptor interaction  hsa04060+1235  
According to Reactome, this protein belongs to the following pathways:
Beta defensins  REACT_115897  
Chemokine receptors bind chemokines  REACT_15344  
G alpha (i) signalling events  REACT_19231  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: C-C_chemokine_receptor_type_6
GenomeRNAi: 1235
PRO: PR:P51684
Chemistry
GuidetoPHARMACOLOGY: 63