CCR8 - C-C chemokine receptor type 8 - human protein (Function)
 
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CCR8 »  C-C chemokine receptor type 8  (CCR-8)
 
Protein also known as:  CC chemokine receptor CHEMR1; CD antigen CDw198.
Gene name:  CCR8
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

 show evidences
Overview 
Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.  
4
  • CuratedUniProtKB
GO molecular function 
C-C chemokine receptor activitydefinition[GO:0016493] silver  
  • IEAOrtholog Compara
Chemokine receptor activitydefinition[GO:0004950]  
1
  • TASPINC
Coreceptor activitydefinition[GO:0015026]  
1
  • TASPINC
GO biological process 
Cell adhesiondefinition[GO:0007155]  
1
  • TASPINC
Chemokine-mediated signaling pathwaydefinition[GO:0070098]  
1
  • TASGOC
  • IEAInterPro 2 GO
  • IEAOrtholog Compara
Chemotaxisdefinition[GO:0006935] silver  
  • IEAOrtholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
  • IEAUniProtKB KW
Immune responsedefinition[GO:0006955] silver  
  • IEAInterPro 2 GO
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204] silver  
  • IEAInterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+1237  
Cytokine-cytokine receptor interaction  hsa04060+1237  
According to Reactome, this protein belongs to the following pathways:
Chemokine receptors bind chemokines  REACT_15344  
G alpha (i) signalling events  REACT_19231  
Caution 
Was originally (PubMed9521068) thought to be a receptor for SCYA3 and SCYA17.  
1
  • CuratedUniProtKB
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CCR8_(gene)
GenomeRNAi: 1237
PRO: PR:P51685
Chemistry
GuidetoPHARMACOLOGY: 65