CCR9 - C-C chemokine receptor type 9 - human protein (Function)
 
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CCR9 »  C-C chemokine receptor type 9  (CCR-9)
 
Protein also known as:  G-protein coupled receptor 28; CD antigen CDw199.
Gene name:  CCR9
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 34 2
GENE REF ISO

Function

 show evidences
Overview 
Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.  
  • CuratedUniProtKB
GO molecular function 
C-C chemokine receptor activitydefinition[GO:0016493] silver  
  • IEAOrtholog Compara
Chemokine receptor activitydefinition[GO:0004950]  
1
  • TASPINC
GO biological process 
Cellular defense responsedefinition[GO:0006968]  
1
  • TASPINC
Chemokine-mediated signaling pathwaydefinition[GO:0070098]  
1
  • TASGOC
Chemotaxisdefinition[GO:0006935] silver  
  • IEAOrtholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • TASPINC
Immune responsedefinition[GO:0006955] silver  
  • IEAInterPro 2 GO
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+10803  
Cytokine-cytokine receptor interaction  hsa04060+10803  
Intestinal immune network for IgA production  hsa04672+10803  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
Note 
EC50 of SCYA25/TECK for isoform 1 is lower than for isoform 2.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CCR9
GenomeRNAi: 10803
PRO: PR:P51686
Chemistry
GuidetoPHARMACOLOGY: 66