SGSH - N-sulphoglucosamine sulphohydrolase - human protein (Function)
 
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Protein
Gene
References

 
SGSH »  N-sulphoglucosamine sulphohydrolase   [ EC 3.10.1.1 ]
 
Protein also known as:  Sulfoglucosamine sulfamidase.
Gene name:  SGSH
Family name: Sulfatase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 32 1
GENE REF ISO

Function

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GO molecular function 
Catalytic activitydefinition[GO:0003824]  
1
  • TASPINC
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
N-sulfoglucosamine sulfohydrolase activitydefinition[GO:0016250]  
  • IEAEC 2 GO
Sulfuric ester hydrolase activitydefinition[GO:0008484] silver  
  • IEAInterPro 2 GO
GO biological process 
Proteoglycan metabolic processdefinition[GO:0006029]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.10.1.1: N-sulfo-D-glucosamine + H(2)O D-glucosamine + sulfate.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 calcium ion per subunit (By similarity).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Glycosaminoglycan degradation  hsa00531+6448  
Lysosome  hsa04142+6448  
Metabolic pathways  hsa01100+6448  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Metabolism  REACT_111217  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SGSH
GenomeRNAi: 6448
PRO: PR:P51688