ARSE - Arylsulfatase E - human protein (Function)
 
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ARSE »  Arylsulfatase E   [ EC 3.1.6.- ]  (ASE)
 
Gene name:  ARSE
Family name: Sulfatase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates.  
  • CuratedUniProtKB
GO molecular function 
Arylsulfatase activitydefinition[GO:0004065]  
1
  • TASPINC
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
GO biological process 
Skeletal system developmentdefinition[GO:0001501]  
1
  • TASPINC
Enzymatic activity 
It requires the following cofactor
Binds 1 calcium ion per subunit (By similarity).  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by millimolar concentrations of warfarin.  
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Metabolism  REACT_111217  
Metabolism of proteins  REACT_17015  
 

Biophysicochemical properties

Dependence
pH Optimum pH is 7.
Temperature Almost completely inactivated after 10 minutes at 50 degrees Celsius.

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Arylsulfatase_E
GenomeRNAi: 415
PRO: PR:P51690