STAT5B - Signal transducer and activator of transcription 5B - human protein (Function)
 
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STAT5B »  Signal transducer and activator of transcription 5B
 
Gene name:  STAT5B
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription.  
1
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Chromatin bindingdefinition[GO:0003682]  
  • ISSOrtholog Curator
Double-stranded DNA bindingdefinition[GO:0003690] silver  
  • IEAOrtholog Compara
Glucocorticoid receptor bindingdefinition[GO:0035259]  
1
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Protein dimerization activitydefinition[GO:0046983]  
  • ISSOrtholog Curator
Protein phosphatase bindingdefinition[GO:0019903] silver  
  • IEAOrtholog Compara
RNA polymerase II core promoter sequence-specific DNA bindingdefinition[GO:0000979] silver  
  • IEAOrtholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAOrtholog Compara
Signal transducer activitydefinition[GO:0004871] silver  
  • IEAOrtholog Compara
GO biological process 
2-oxoglutarate metabolic processdefinition[GO:0006103]  
  • ISSOrtholog Curator
Acute-phase responsedefinition[GO:0006953] silver  
  • IEAOrtholog Compara
Allantoin metabolic processdefinition[GO:0000255]  
  • ISSOrtholog Curator
Cellular response to epidermal growth factor stimulusdefinition[GO:0071364]  
  • ISSOrtholog Curator
Cellular response to growth factor stimulusdefinition[GO:0071363]  
  • ISSOrtholog Curator
Cellular response to hormone stimulusdefinition[GO:0032870]  
1
  • IDABHF-UCL
Citrate metabolic processdefinition[GO:0006101]  
  • ISSOrtholog Curator
Creatine metabolic processdefinition[GO:0006600]  
  • ISSOrtholog Curator
Creatinine metabolic processdefinition[GO:0046449]  
  • ISSOrtholog Curator
Development of secondary female sexual characteristicsdefinition[GO:0046543] silver  
  • IEAOrtholog Compara
Development of secondary male sexual characteristicsdefinition[GO:0046544] silver  
  • IEAOrtholog Compara
Fatty acid metabolic processdefinition[GO:0006631]  
  • ISSOrtholog Curator
Female pregnancydefinition[GO:0007565] silver  
  • IEAOrtholog Compara
Isoleucine metabolic processdefinition[GO:0006549]  
  • ISSOrtholog Curator
JAK-STAT cascadedefinition[GO:0007259]  
1
  • TASPINC
JAK-STAT cascade involved in growth hormone signaling pathwaydefinition[GO:0060397]  
1
  • IDABHF-UCL
Lactationdefinition[GO:0007595] silver  
  • IEAOrtholog Compara
Lipid storagedefinition[GO:0019915] silver  
  • IEAOrtholog Compara
Liver developmentdefinition[GO:0001889] silver  
  • IEAOrtholog Compara
Luteinizationdefinition[GO:0001553] silver  
  • IEAOrtholog Compara
Natural killer cell differentiationdefinition[GO:0001779] silver  
  • IEAOrtholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
  • IEAOrtholog Compara
Negative regulation of erythrocyte differentiationdefinition[GO:0045647] silver  
  • IEAOrtholog Compara
Oxaloacetate metabolic processdefinition[GO:0006107]  
  • ISSOrtholog Curator
Peyer's patch developmentdefinition[GO:0048541] silver  
  • IEAOrtholog Compara
Positive regulation of activated T cell proliferationdefinition[GO:0042104] silver  
  • IEAOrtholog Compara
Positive regulation of B cell differentiationdefinition[GO:0045579] silver  
  • IEAOrtholog Compara
Positive regulation of cellular component movementdefinition[GO:0051272] silver  
  • IEAOrtholog Compara
Positive regulation of gamma-delta T cell differentiationdefinition[GO:0045588] silver  
  • IEAOrtholog Compara
Positive regulation of inflammatory responsedefinition[GO:0050729] silver  
  • IEAOrtholog Compara
Positive regulation of interleukin-2 biosynthetic processdefinition[GO:0045086] silver  
  • IEAOrtholog Compara
Positive regulation of mitotic cell cycledefinition[GO:0045931] silver  
  • IEAOrtholog Compara
Positive regulation of multicellular organism growthdefinition[GO:0040018] silver  
  • IEAOrtholog Compara
Positive regulation of natural killer cell differentiationdefinition[GO:0032825] silver  
  • IEAOrtholog Compara
Positive regulation of natural killer cell mediated cytotoxicitydefinition[GO:0045954] silver  
  • IEAOrtholog Compara
Positive regulation of natural killer cell proliferationdefinition[GO:0032819] silver  
  • IEAOrtholog Compara
Positive regulation of smooth muscle cell proliferationdefinition[GO:0048661] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
  • ISSOrtholog Curator
Progesterone metabolic processdefinition[GO:0042448] silver  
  • IEAOrtholog Compara
Prolactin signaling pathwaydefinition[GO:0038161]  
  • ISSOrtholog Curator
Regulation of cell adhesiondefinition[GO:0030155] silver  
  • IEAOrtholog Compara
Regulation of epithelial cell differentiationdefinition[GO:0030856] silver  
  • IEAOrtholog Compara
Regulation of multicellular organism growthdefinition[GO:0040014]  
  • ISSOrtholog Curator
Regulation of steroid metabolic processdefinition[GO:0019218] silver  
  • IEAOrtholog Compara
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • TASPINC
Response to estradioldefinition[GO:0032355]  
1
  • IDABHF-UCL
Response to ethanoldefinition[GO:0045471] silver  
  • IEAOrtholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
  • IEAOrtholog Compara
Response to interleukin-15definition[GO:0070672] silver  
  • IEAOrtholog Compara
Response to interleukin-2definition[GO:0070669] silver  
  • IEAOrtholog Compara
Response to interleukin-4definition[GO:0070670] silver  
  • IEAOrtholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
Succinate metabolic processdefinition[GO:0006105]  
  • ISSOrtholog Curator
T cell differentiation in thymusdefinition[GO:0033077] silver  
  • IEAOrtholog Compara
T cell homeostasisdefinition[GO:0043029] silver  
  • IEAOrtholog Compara
Taurine metabolic processdefinition[GO:0019530]  
  • ISSOrtholog Curator
Transcription from RNA polymerase II promoterdefinition[GO:0006366] silver  
  • IEAOrtholog Compara
Valine metabolic processdefinition[GO:0006573]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Acute myeloid leukemia  hsa05221+6777  
Chemokine signaling pathway  hsa04062+6777  
Chronic myeloid leukemia  hsa05220+6777  
ErbB signaling pathway  hsa04012+6777  
HTLV-I infection  hsa05166+6777  
Jak-STAT signaling pathway  hsa04630+6777  
Measles  hsa05162+6777  
Pathways in cancer  hsa05200+6777  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Immune System  REACT_6900  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: STAT5B
GenomeRNAi: 6777
PRO: PR:P51692