STAT5B - Signal transducer and activator of transcription 5B - human protein (Function)
 
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STAT5B »  Signal transducer and activator of transcription 5B
 
Gene name:  STAT5B
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription.  
2
  • UniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682]  
1
  • Ortholog Curator
DNA bindingdefinition[GO:0003677]  
1
  • UniProtKB KW
Glucocorticoid receptor bindingdefinition[GO:0035259]  
1
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
Protein dimerization activitydefinition[GO:0046983]  
1
  • Ortholog Curator
Signal transducer activitydefinition[GO:0004871] silver  
1
  • InterPro 2 GO
Transcription factor activity, sequence-specific DNA bindingdefinition[GO:0003700] silver  
1
  • InterPro 2 GO
GO biological process 
2-oxoglutarate metabolic processdefinition[GO:0006103]  
1
  • Ortholog Curator
Allantoin metabolic processdefinition[GO:0000255]  
1
  • Ortholog Curator
Cellular response to epidermal growth factor stimulusdefinition[GO:0071364]  
1
  • Ortholog Curator
Cellular response to growth factor stimulusdefinition[GO:0071363]  
1
  • Ortholog Curator
Cellular response to hormone stimulusdefinition[GO:0032870]  
1
  • BHF-UCL
Citrate metabolic processdefinition[GO:0006101]  
1
  • Ortholog Curator
Creatine metabolic processdefinition[GO:0006600]  
1
  • Ortholog Curator
Creatinine metabolic processdefinition[GO:0046449]  
1
  • Ortholog Curator
Fatty acid metabolic processdefinition[GO:0006631]  
1
  • Ortholog Curator
Isoleucine metabolic processdefinition[GO:0006549]  
1
  • Ortholog Curator
JAK-STAT cascadedefinition[GO:0007259]  
1
  • PINC
JAK-STAT cascade involved in growth hormone signaling pathwaydefinition[GO:0060397]  
1
  • BHF-UCL
Oxaloacetate metabolic processdefinition[GO:0006107]  
1
  • Ortholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • Ortholog Curator
Prolactin signaling pathwaydefinition[GO:0038161]  
1
  • Ortholog Curator
Regulation of multicellular organism growthdefinition[GO:0040014]  
1
  • Ortholog Curator
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • PINC
Response to estradioldefinition[GO:0032355]  
1
  • BHF-UCL
Succinate metabolic processdefinition[GO:0006105]  
1
  • Ortholog Curator
Taurine metabolic processdefinition[GO:0019530]  
1
  • Ortholog Curator
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
Valine metabolic processdefinition[GO:0006573]  
1
  • Ortholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Acute myeloid leukemia  hsa05221+6777  
Chemokine signaling pathway  hsa04062+6777  
Chronic myeloid leukemia  hsa05220+6777  
ErbB signaling pathway  hsa04012+6777  
HTLV-I infection  hsa05166+6777  
Jak-STAT signaling pathway  hsa04630+6777  
Measles  hsa05162+6777  
Pathways in cancer  hsa05200+6777  
According to Reactome, this protein belongs to the following pathways:
Downstream signal transduction  R-HSA-186763  
Growth hormone receptor signaling  R-HSA-982772  
Interleukin-2 signaling  R-HSA-451927  
Interleukin-3, 5 and GM-CSF signaling  R-HSA-512988  
Interleukin-7 signaling  R-HSA-1266695  
Prolactin receptor signaling  R-HSA-1170546  
Signaling by FGFR1 fusion mutants  R-HSA-1839117  
Signaling by Leptin  R-HSA-2586552  
Signaling by SCF-KIT  R-HSA-1433557  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: STAT5B
GenomeRNAi: 6777
PRO: PR:P51692