USP11 - Ubiquitin carboxyl-terminal hydrolase 11 - human protein (Function)
 
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Protein
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References

 
USP11 »  Ubiquitin carboxyl-terminal hydrolase 11   [ EC 3.4.19.12 ]
 
Protein also known as:  Ubiquitin-specific-processing protease 11.
Gene name:  USP11
Family name: Peptidase C19
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks.  
5
  • CuratedUniProtKB
GO molecular function 
Cysteine-type endopeptidase activitydefinition[GO:0004197]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
  • IPIUniProtKB
Ubiquitin-specific protease activitydefinition[GO:0004843]  
1
  • IDAUniProtKB
GO biological process 
Protein deubiquitinationdefinition[GO:0016579]  
1
  • IDAUniProtKB
Ubiquitin-dependent protein catabolic processdefinition[GO:0006511] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.19.12: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Association of TriC/CCT with target proteins during biosynthesis  REACT_16907  
 

Keywords

Biological process 
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: USP11
GenomeRNAi: 8237
PRO: PR:P51784