KCNQ1 - Potassium voltage-gated channel subfamily KQT member 1 - human protein (Function)
 
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KCNQ1 »  Potassium voltage-gated channel subfamily KQT member 1
 
Protein also known as:  IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1.
Gene name:  KCNQ1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 85 2
GENE REF ISO

Function

 show evidences
Overview 
Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the voltage-gated ion channel (vic) superfamily  1.A.1.15.6  
GO molecular function 
Calmodulin bindingdefinition[GO:0005516]  
1
  • IDABHF-UCL
Contributes to delayed rectifier potassium channel activitydefinition[GO:0005251]  
5
  • IDABHF-UCL
Ion channel bindingdefinition[GO:0044325]  
1
  • IPIBHF-UCL
Outward rectifier potassium channel activitydefinition[GO:0015271] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
Protein kinase A catalytic subunit bindingdefinition[GO:0034236]  
1
  • IDABHF-UCL
Protein kinase A regulatory subunit bindingdefinition[GO:0034237]  
1
  • IDABHF-UCL
Protein phosphatase 1 bindingdefinition[GO:0008157]  
1
  • IDABHF-UCL
Scaffold protein bindingdefinition[GO:0097110]  
1
  • IPIBHF-UCL
Voltage-gated potassium channel activitydefinition[GO:0005249]  
2
  • IDABHF-UCL
Voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarizationdefinition[GO:0086089]  
1
  • IMPBHF-UCL
Voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarizationdefinition[GO:0086008]  
1
  • IMPBHF-UCL
Voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarizationdefinition[GO:1902282]  
1
  • IMPBHF-UCL
GO biological process 
Atrial cardiac muscle cell action potentialdefinition[GO:0086014]  
1
  • IMPBHF-UCL
Cardiac muscle contractiondefinition[GO:0060048]  
1
  • IMPBHF-UCL
Cardiovascular system developmentdefinition[GO:0072358] silver  
  • IEAOrtholog Compara
Cellular response to cAMPdefinition[GO:0071320]  
1
  • IDABHF-UCL
Cellular response to drugdefinition[GO:0035690]  
1
  • IDABHF-UCL
Cellular response to epinephrine stimulusdefinition[GO:0071872]  
1
  • TASBHF-UCL
Gene silencingdefinition[GO:0016458] silver  
  • IEAOrtholog Compara
Male gonad developmentdefinition[GO:0008584] silver  
  • IEAOrtholog Compara
Membrane repolarization during action potentialdefinition[GO:0086011]  
2
  • IDABHF-UCL
Membrane repolarization during cardiac muscle cell action potentialdefinition[GO:0086013]  
2
  • TASBHF-UCL
Negative regulation of insulin secretiondefinition[GO:0046676] silver  
  • IEAOrtholog Compara
Positive regulation of gastric acid secretiondefinition[GO:0060454] silver  
  • IEAOrtholog Compara
Positive regulation of potassium ion transmembrane transportdefinition[GO:1901381]  
1
  • IDABHF-UCL
Potassium ion exportdefinition[GO:0071435]  
3
  • IDABHF-UCL
Potassium ion transmembrane transportdefinition[GO:0071805]  
2
  • IDABHF-UCL
Regulation of atrial cardiac muscle cell membrane repolarizationdefinition[GO:0060372]  
1
  • IMPBHF-UCL
Regulation of gene expression by genetic imprintingdefinition[GO:0006349] silver  
  • IEAOrtholog Compara
Regulation of heart contractiondefinition[GO:0008016]  
1
  • ICBHF-UCL
Regulation of heart rate by cardiac conductiondefinition[GO:0086091]  
1
  • IMPBHF-UCL
Regulation of membrane repolarizationdefinition[GO:0060306]  
2
  • IDABHF-UCL
Regulation of ventricular cardiac muscle cell membrane repolarizationdefinition[GO:0060307]  
1
  • IMPBHF-UCL
Sensory perception of sounddefinition[GO:0007605]  
1
  • TASPINC
Ventricular cardiac muscle cell action potentialdefinition[GO:0086005]  
1
  • IMPBHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cholinergic synapse  hsa04725+3784  
Gastric acid secretion  hsa04971+3784  
Pancreatic secretion  hsa04972+3784  
Protein digestion and absorption  hsa04974+3784  
Vibrio cholerae infection  hsa05110+3784  
According to Reactome, this protein belongs to the following pathway:
Voltage gated Potassium channels  REACT_75770  
Note 
Mutagenesis experiments were carried out by expressing in Xenopus oocytes or COS-7 cells KCNQ1 mutants either individually (homomultimers) or in combination with both wild-type KCNQ1 (mut/wt homomultimers) and minK (heteromultimers).  
  • CuratedUniProtKB
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Potassium channel  definition   [KW-0631]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: KvLQT1
GenomeRNAi: 3784
PRO: PR:P51787
Chemistry
GuidetoPHARMACOLOGY: 560