CLCN5 - H(+)/Cl(-) exchange transporter 5 - human protein (Function)
 
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Protein
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References

 
CLCN5 »  H(+)/Cl(-) exchange transporter 5
 
Protein also known as:  Chloride channel protein 5 (ClC-5).
Gene name:  CLCN5
Entry whose protein(s) existence is based on evidence at protein level
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1 72 2
GENE REF ISO

Function

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Overview 
Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function.  
  • CuratedUniProtKB
GO molecular function 
Antiporter activitydefinition[GO:0015297]  
  • IEAUniProtKB KW
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Chloride channel activitydefinition[GO:0005254]  
1
  • TASPINC
Voltage-gated chloride channel activitydefinition[GO:0005247] silver  
  • IEAOrtholog Compara
GO biological process 
Chloride transmembrane transportdefinition[GO:1902476]  
1
  • TASGOC
Endocytosisdefinition[GO:0006897] silver  
  • IEAOrtholog Compara
Excretiondefinition[GO:0007588]  
1
  • TASPINC
Transportdefinition[GO:0006810]  
1
  • TASPINC
Pathways 
According to Reactome, this protein belongs to the following pathway:
Transmembrane transport of small molecules  REACT_15518  
Note 
The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Antiport  definition   [KW-0050]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CLCN5
GenomeRNAi: 1184
PRO: PR:P51795