CLCN6 - Chloride transport protein 6 - human protein (Function)
 
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CLCN6 »  Chloride transport protein 6
 
Protein also known as:  Chloride channel protein 6 (ClC-6).
Gene name:  CLCN6
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 23 6
GENE REF ISO

Function

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Overview 
Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter.  
  • CuratedUniProtKB
GO molecular function 
Antiporter activitydefinition[GO:0015297]  
  • IEAUniProtKB KW
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Voltage-gated chloride channel activitydefinition[GO:0005247]  
2
  • NASUniProtKB
GO biological process 
Cell volume homeostasisdefinition[GO:0006884]  
2
  • NASUniProtKB
Chloride transportdefinition[GO:0006821]  
2
  • NASUniProtKB
Regulation of anion transportdefinition[GO:0044070]  
2
  • NASGOC
Response to mechanical stimulusdefinition[GO:0009612] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
2
  • NASUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Transmembrane transport of small molecules  REACT_15518  
Note 
The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity).  
  • CuratedUniProtKB
 

Keywords

Biological process 
Antiport  definition   [KW-0050]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CLCN6
GenomeRNAi: 1185
PRO: PR:P51797
Chemistry
GuidetoPHARMACOLOGY: 705