CLCN7 - H(+)/Cl(-) exchange transporter 7 - human protein (Function)
 
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Protein
Gene
References

 
CLCN7 »  H(+)/Cl(-) exchange transporter 7
 
Protein also known as:  Chloride channel 7 alpha subunit.
Gene name:  CLCN7
Entry whose protein(s) existence is based on evidence at protein level
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1 42 2
GENE REF ISO

Function

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Overview 
Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen.  
2
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the chloride carrier/channel (clc) family  2.A.49.3.3  
GO molecular function 
Antiporter activitydefinition[GO:0015297]  
  • IEAUniProtKB KW
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Chloride channel activitydefinition[GO:0005254]  
1
  • TASPINC
Voltage-gated chloride channel activitydefinition[GO:0005247] silver  
  • IEAInterPro 2 GO
GO biological process 
Chloride transmembrane transportdefinition[GO:1902476]  
1
  • TASGOC
Regulation of anion transportdefinition[GO:0044070]  
  • IEAInterPro 2 GO
Response to pHdefinition[GO:0009268] silver  
  • IEAOrtholog Compara
Transportdefinition[GO:0006810]  
1
  • TASPINC
Pathways 
According to Reactome, this protein belongs to the following pathway:
Stimuli-sensing channels  REACT_160189  
Note 
The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity).  
  • CuratedUniProtKB
 

Keywords

Biological process 
Antiport  definition   [KW-0050]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CLCN7
GenomeRNAi: 1186
PRO: PR:P51798
Chemistry
GuidetoPHARMACOLOGY: 706