BMX - Cytoplasmic tyrosine-protein kinase BMX - human protein (Function)
 
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BMX »  Cytoplasmic tyrosine-protein kinase BMX   [ EC 2.7.10.2 ]
 
Protein also known as:  Bone marrow tyrosine kinase gene in chromosome X protein.
Gene name:  BMX
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 61 1
GENE REF ISO

Function

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Overview 
Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells.  
8
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Non-membrane spanning protein tyrosine kinase activitydefinition[GO:0004715]  
2
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IntAct
  • UniProtKB
Protein tyrosine kinase activitydefinition[GO:0004713]  
1
  • PINC
Not  Receptor bindingdefinition[GO:0005102]  
1
  • RefGenome
Signal transducer activitydefinition[GO:0004871]  
1
  • PINC
GO biological process 
Adaptive immune responsedefinition[GO:0002250]  
1
  • RefGenome
Not  B cell receptor signaling pathwaydefinition[GO:0050853]  
1
  • RefGenome
Cell adhesiondefinition[GO:0007155]  
1
  • UniProtKB KW
Cell differentiationdefinition[GO:0030154]  
1
  • RefGenome
Innate immune responsedefinition[GO:0045087]  
1
  • RefGenome
Intracellular signal transductiondefinition[GO:0035556] silver  
1
  • InterPro 2 GO
Mesoderm developmentdefinition[GO:0007498]  
1
  • PINC
Peptidyl-tyrosine autophosphorylationdefinition[GO:0038083]  
1
  • RefGenome
Protein autophosphorylationdefinition[GO:0046777]  
1
  • UniProtKB
Protein phosphorylationdefinition[GO:0006468]  
1
  • PINC
Regulation of cell proliferationdefinition[GO:0042127]  
1
  • RefGenome
Signal transductiondefinition[GO:0007165]  
2
  • UniProtKB
Not  T cell receptor signaling pathwaydefinition[GO:0050852]  
1
  • RefGenome
Transmembrane receptor protein tyrosine kinase signaling pathwaydefinition[GO:0007169]  
1
  • RefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.2: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
2
  • UniProtKB
  • PROSITE-ProRule
It requires the following cofactor
 Zn(2+) : Binds 1 zinc ion per subunit.  
1
  • UniProtKB
It is regulated in the following manner
TEK and vascular endothelial growth factor receptor 1 (FLT1) stimulate BMX tyrosine kinase activity (By similarity). Activated by integrins through the mediation of PTK2/FAK1. Activated by TNF through the mediation of TNFRSF1B.  
4
  • UniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Apoptotic cleavage of cellular proteins  REACT_107  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Cell adhesion  definition   [KW-0130]
Stress response  definition   [KW-0346]
Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: BMX_(gene)
GenomeRNAi: 660
PRO: PR:P51813
Chemistry
GuidetoPHARMACOLOGY: 1942