ADCY7 - Adenylate cyclase type 7 - human protein (Function)
 
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ADCY7 »  Adenylate cyclase type 7   [ EC 4.6.1.1 ]
 
Protein also known as:  Adenylate cyclase type VII.
Gene name:  ADCY7
Entry whose protein(s) existence is based on evidence at protein level
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1 27 1
GENE REF ISO

Function

 show evidences
Overview 
This is a membrane-bound, calcium-inhibitable adenylyl cyclase.  
  • CuratedUniProtKB
GO molecular function 
Adenylate cyclase activitydefinition[GO:0004016]  
2
  • IDAUniProtKB
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
GO biological process 
cAMP biosynthetic processdefinition[GO:0006171] silver  
  • IEAOrtholog Compara
Cellular response to ethanoldefinition[GO:0071361]  
1
  • IDAUniProtKB
Intracellular signal transductiondefinition[GO:0035556] silver  
  • IEAInterPro 2 GO
Maternal process involved in female pregnancydefinition[GO:0060135] silver  
  • IEAOrtholog Compara
Positive regulation of cAMP biosynthetic processdefinition[GO:0030819]  
2
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.6.1.1: ATP 3',5'-cyclic AMP + diphosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 2 magnesium ions per subunit (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bile secretion  hsa04976+113  
Calcium signaling pathway  hsa04020+113  
Chemokine signaling pathway  hsa04062+113  
Cholinergic synapse  hsa04725+113  
Dilated cardiomyopathy  hsa05414+113  
GABAergic synapse  hsa04727+113  
Gap junction  hsa04540+113  
Gastric acid secretion  hsa04971+113  
Glutamatergic synapse  hsa04724+113  
GnRH signaling pathway  hsa04912+113  
HTLV-I infection  hsa05166+113  
Melanogenesis  hsa04916+113  
Oocyte meiosis  hsa04114+113  
Pancreatic secretion  hsa04972+113  
Progesterone-mediated oocyte maturation  hsa04914+113  
Purine metabolism  hsa00230+113  
Salivary secretion  hsa04970+113  
Vascular smooth muscle contraction  hsa04270+113  
According to Reactome, this protein belongs to the following pathways:
Adenylate cyclase activating pathway  REACT_15312  
Adenylate cyclase inhibitory pathway  REACT_15333  
G alpha (i) signalling events  REACT_19231  
G alpha (s) signalling events  REACT_19327  
G alpha (z) signalling events  REACT_19333  
Glucagon signaling in metabolic regulation  REACT_1665  
PKA activation  REACT_15530  
PKA activation in glucagon signalling  REACT_1946  
Regulation of water balance by renal Aquaporins  REACT_24023  
 

Keywords

Biological process 
cAMP biosynthesis  definition   [KW-0115]
Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ADCY7
GenomeRNAi: 113
PRO: PR:P51828