GUCY2F - Retinal guanylyl cyclase 2 - human protein (Function)
 
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Protein
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References

 
GUCY2F »  Retinal guanylyl cyclase 2   [ EC 4.6.1.2 ]  (RETGC-2)
 
Protein also known as:  Rod outer segment membrane guanylate cyclase 2 (ROS-GC2).
Gene name:  GUCY2F
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 26 1
GENE REF ISO

Function

 show evidences
Overview 
Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524] silver  
  • IEAInterPro 2 GO
GTP bindingdefinition[GO:0005525]  
  • IEAUniProtKB KW
Guanylate cyclase activitydefinition[GO:0004383]  
  • IEAEC 2 GO
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
Protein kinase activitydefinition[GO:0004672] silver  
  • IEAInterPro 2 GO
Receptor activitydefinition[GO:0004872]  
1
  • TASPINC
GO biological process 
Intracellular signal transductiondefinition[GO:0035556] silver  
  • IEAInterPro 2 GO
Receptor guanylyl cyclase signaling pathwaydefinition[GO:0007168]  
1
  • TASPINC
Visual perceptiondefinition[GO:0007601]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.6.1.2: GTP 3',5'-cyclic GMP + diphosphate.  
  • CuratedUniProtKB
It is regulated in the following manner
Activated by GCAP-1; inhibited by calcium.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Phototransduction  hsa04744+2986  
Purine metabolism  hsa00230+2986  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Sensory transduction  definition   [KW-0716]
Vision  definition   [KW-0844]
cGMP biosynthesis  definition   [KW-0141]
Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 2986
PRO: PR:P51841