NR0B1 - Nuclear receptor subfamily 0 group B member 1 - human protein (Function)
 
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NR0B1 »  Nuclear receptor subfamily 0 group B member 1
 
Protein also known as:  DSS-AHC critical region on the X chromosome protein 1.
Gene name:  NR0B1
Family name: Nuclear hormone receptor » NR0
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 109 2
GENE REF ISO

Function

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Overview 
Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Isoform  Iso 2   AF-2 domain bindingdefinition[GO:0050682]  
1
  • IPIUniProtKB
DNA bindingdefinition[GO:0003677]  
1
  • IDAHGNC
DNA hairpin bindingdefinition[GO:0032448]  
1
  • IDAHGNC
Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0004879]  
2
  • NASUniProtKB
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
4
  • IPIUniProtKB
  • IPIIntAct
Protein domain specific bindingdefinition[GO:0019904]  
2
  • IPIUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIUniProtKB
RNA bindingdefinition[GO:0003723]  
1
  • IDAHGNC
Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • IDAHGNC
Steroid hormone receptor activitydefinition[GO:0003707] silver  
  • IEAInterPro 2 GO
Steroid hormone receptor bindingdefinition[GO:0035258]  
1
  • IPIUniProtKB
Transcription corepressor activitydefinition[GO:0003714]  
1
  • IMPBHF-UCL
Transcription factor bindingdefinition[GO:0008134]  
1
  • IPIBHF-UCL
GO biological process 
Adrenal gland developmentdefinition[GO:0030325]  
1
  • IMPHGNC
Gonad developmentdefinition[GO:0008406]  
1
  • IMPHGNC
Hypothalamus developmentdefinition[GO:0021854]  
1
  • NASUniProtKB
Intracellular receptor signaling pathwaydefinition[GO:0030522]  
2
  • NASGOC
Leydig cell differentiationdefinition[GO:0033327] silver  
  • IEAOrtholog Compara
Male gonad developmentdefinition[GO:0008584]  
1
  • IMPUniProtKB
Male sex determinationdefinition[GO:0030238] silver  
  • IEAOrtholog Compara
Negative regulation of cell differentiationdefinition[GO:0045596] silver  
  • IEAOrtholog Compara
Negative regulation of intracellular steroid hormone receptor signaling pathwaydefinition[GO:0033144]  
1
  • IDAUniProtKB
Negative regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0043433]  
1
  • IMPBHF-UCL
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
3
  • IMPBHF-UCL
  • IDAHGNC
Pituitary gland developmentdefinition[GO:0021983]  
1
  • NASUniProtKB
Protein localizationdefinition[GO:0008104]  
1
  • IDAUniProtKB
Response to immobilization stressdefinition[GO:0035902] silver  
  • IEAOrtholog Compara
Sertoli cell differentiationdefinition[GO:0060008] silver  
  • IEAOrtholog Compara
Spermatogenesisdefinition[GO:0007283] silver  
  • IEAOrtholog Compara
Steroid biosynthetic processdefinition[GO:0006694]  
1
  • IDAHGNC
Pathways 
According to Reactome, this protein belongs to the following pathway:
Gene Expression  REACT_71  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Receptor  definition   [KW-0675]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: DAX1
GenomeRNAi: 190
PRO: PR:P51843