AKR1D1 - 3-oxo-5-beta-steroid 4-dehydrogenase - human protein (Function)
 
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AKR1D1 »  3-oxo-5-beta-steroid 4-dehydrogenase   [ EC 1.3.1.3 ]
 
Protein also known as:  Delta(4)-3-ketosteroid 5-beta-reductase.
Gene name:  AKR1D1
Family name: Aldo/keto reductase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 32 3
GENE REF ISO

Function

 show evidences
Overview 
Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4-cholesten-3-one can also act as substrates.  
  • CuratedUniProtKB
GO molecular function 
Delta4-3-oxosteroid 5beta-reductase activitydefinition[GO:0047787]  
  • IEAEC 2 GO
Steroid bindingdefinition[GO:0005496]  
1
  • TASUniProtKB
GO biological process 
Androgen metabolic processdefinition[GO:0008209]  
1
  • IDAUniProtKB
Bile acid biosynthetic processdefinition[GO:0006699]  
1
  • IDAUniProtKB
Bile acid catabolic processdefinition[GO:0030573]  
  • IEAUniProtKB KW
C21-steroid hormone metabolic processdefinition[GO:0008207]  
1
  • IDAUniProtKB
Cholesterol catabolic processdefinition[GO:0006707]  
1
  • IDAUniProtKB
Digestiondefinition[GO:0007586]  
1
  • IDAUniProtKB
Oxidation-reduction processdefinition[GO:0055114]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
5-beta-cholestan-3-one + NADP(+) cholest-4-en-3-one + NADPH.  
  • CuratedUniProtKB
17,21-dihydroxy-5-beta-pregnane-3,11,20-trione + NADP(+) cortisone.  
  • CuratedUniProtKB
It is regulated in the following manner
Subject to inhibition by high substrate concentrations. Inhibited by testosterone concentrations above 10 uM.  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+6718  
Primary bile acid biosynthesis  hsa00120+6718  
Steroid hormone biosynthesis  hsa00140+6718  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Biophysicochemical properties

Kinetic parameters
KM 2.7 uM for testosterone

Keywords

Biological process 
Bile acid catabolism  definition   [KW-0088]
Lipid degradation  definition   [KW-0442]
Lipid metabolism  definition   [KW-0443]
Steroid metabolism  definition   [KW-0753]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P51857
Other
GenomeRNAi: 6718
PRO: PR:P51857